Seroatlas · Human Serome Atlas

PFN3

Profilin-3

Also known as: PROF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P60673
Gene: PFN3
Ensembl: ENSG00000196570
Chromosome: 5
Canonical length: 137 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

The product of this gene belongs to the profilin family of proteins. This protein binds to actin and affects the structure of the cytoskeleton. It also may be involved in spermatogenesis. It is a single exon gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>P60673|PFN3
     1  MGDWKVYISA VLRDQRIDDV AIVGHADNSC VWASRPGGLL AAISPQEVGV LTGPDRHTFL
    61  QAGLSVGGRR CCVIRDHLLA EGDGVLDART KGLDARAVCV GRAPRALLVL MGRRGVHGGI
   121  LNKTVHELIR GLRMQGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PFN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
kidney: 0.8 nTPM
liver: 0.3 nTPM
basal ganglia: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 2,309 nCPM
early spermatids: 847 nCPM
late primary spermatocytes: 107 nCPM
sertoli cells: 7.4 nCPM
undifferentiated spermatogonia: 4.2 nCPM
epididymal clear cells: 4.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0.5
gnomAD missense Z: 0.48
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PFN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACTRT3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PFN3 as an antibody target. Whether an autoantibody or antibody against PFN3 could matter depends on whether native PFN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PFN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PFN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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