Seroatlas · Human Serome Atlas

ZDHHC12

Palmitoyltransferase ZDHHC12

Also known as: FLJ14524, ZDH12_HUMAN, ZNF400

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GR4
Gene: ZDHHC12
Ensembl: ENSG00000160446
Chromosome: 9
Canonical length: 267 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Intermediate filaments

OverviewNCBI Gene

Enables protein-cysteine S-palmitoyltransferase activity. Involved in gephyrin clustering involved in postsynaptic density assembly; negative regulation of NLRP3 inflammasome complex assembly; and protein palmitoylation. Located in Golgi apparatus and endoplasmic reticulum. Is active in dendritic spine. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>Q96GR4|ZDHHC12
     1  MAPWALLSPG VLVRTGHTVL TWGITLVLFL HDTELRQWEE QGELLLPLTF LLLVLGSLLL
    61  YLAVSLMDPG YVNVQPQPQE ELKEEQTAMV PPAIPLRRCR YCLVLQPLRA RHCRECRRCV
   121  RRYDHHCPWM ENCVGERNHP LFVVYLALQL VVLLWGLYLA WSGLRFFQPW GQWLRSSGLL
   181  FATFLLLSLF SLVASLLLVS HLYLVASNTT TWEFISSHRI AYLRQRPSNP FDRGLTRNLA
   241  HFFCGWPSGS WETLWAEEEE EGSSPAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

esophagus: 60 nTPM
pancreas: 59 nTPM
liver: 47 nTPM
stomach: 43 nTPM
bone marrow: 39 nTPM
salivary gland: 38 nTPM

Single-cell type

extravillous trophoblasts: 286 nCPM
esophageal apical cells: 229 nCPM
esophageal suprabasal cells: 223 nCPM
cytotrophoblasts: 215 nCPM
esophageal basal cells: 190 nCPM
migrating cytotrophoblasts: 188 nCPM

Immune cell

eosinophil: 387 nTPM
neutrophil: 271 nTPM
plasmacytoid DC: 245 nTPM
basophil: 232 nTPM
non-classical monocyte: 151 nTPM
T-reg: 131 nTPM

Brain region

thalamus: 15 nTPM
medulla oblongata: 13 nTPM
white matter: 13 nTPM
hypothalamus: 11 nTPM
pons: 10 nTPM
choroid plexus: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ABHD8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC12 as an antibody target. Whether an autoantibody or antibody against ZDHHC12 could matter depends on whether native ZDHHC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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