Astacin (Peptidase family M12A)
PF01400
Definition
The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin [swissprot:P07584], a digestive enzyme from Crayfish. Meprin, [swissprot:Q16819], a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as [swissprot:P13497], and Tolloid from drosophila [swissprot:P25723].
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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