Seroatlas · Human Serome Atlas

ASTL

Astacin-like metalloendopeptidase

Also known as: ASTL_HUMAN, ovastacin, SAS1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6HA08
Gene
ASTL
Ensembl
ENSG00000188886
Chromosome
2
Canonical length
431 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Predicted to be located in cortical granule and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q6HA08|ASTL
     1  MEGVGGLWPW VLGLLSLPGV ILGAPLASSC AGACGTSFPD GLTPEGTQAS GDKDIPAINQ
    61  GLILEETPES SFLIEGDIIR PSPFRLLSAT SNKWPMGGSG VVEVPFLLSS KYDEPSRQVI
   121  LEALAEFERS TCIRFVTYQD QRDFISIIPM YGCFSSVGRS GGMQVVSLAP TCLQKGRGIV
   181  LHELMHVLGF WHEHTRADRD RYIRVNWNEI LPGFEINFIK SQSSNMLTPY DYSSVMHYGR
   241  LAFSRRGLPT ITPLWAPSVH IGQRWNLSAS DITRVLKLYG CSPSGPRPRG RGSHAHSTGR
   301  SPAPASLSLQ RLLEALSAES RSPDPSGSSA GGQPVPAGPG ESPHGWESPA LKKLSAEASA
   361  RQPQTLASSP RSRPGAGAPG VAQEQSWLAG VSTKPTVPSS EAGIQPVPVQ GSPALPGGCV
   421  PRNHFKGMSE D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASTL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
3.7 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 3.7 nTPM
  • urinary bladder: 1.7 nTPM
  • skin: 1.1 nTPM
  • ovary: 1 nTPM
  • seminal vesicle: 1 nTPM
  • spleen: 1 nTPM

Single-cell type

  • endometrial luminal cells: 72 nCPM
  • innate lymphoid cells: 57 nCPM
  • cdc: 56 nCPM
  • nk-cells: 55 nCPM
  • endometrial glandular cells: 53 nCPM
  • monocytes: 44 nCPM

Immune cell

  • NK-cell: 0.4 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 7.2 nTPM
  • amygdala: 1.5 nTPM
  • cerebellum: 1.3 nTPM
  • hippocampal formation: 1.1 nTPM
  • white matter: 0.6 nTPM
  • basal ganglia: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ASTL.

Disease | AllUniProt

Conditions ASTL is implicated in, by any mechanism.

  • Oocyte/zygote/embryo maturation arrest 11 (OZEMA11) MIM:619643

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 94 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Oocyte maturation defect 11

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.29
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASTL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASTL as an antibody target. Whether an autoantibody or antibody against ASTL could matter depends on whether native ASTL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASTL is annotated at the cell surface, where native ASTL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ASTL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASTL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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