Notch and Slit guidance protein
IPR051355
Definition
This family of proteins includes members that are involved in various cellular and developmental processes, such as neural progenitor proliferation, brain neocortex expansion, and axonal guidance. They function by modulating the Notch signaling pathway, which influences cell fate determination, differentiation, proliferation, and apoptosis. Some family members interact with membrane-bound ligands and receptors to activate transcriptional activator complexes, while others act as molecular guidance cues for cellular migration by interacting with roundabout homolog receptors. They are implicated in neural development, bone remodeling, and leukocyte migration, and may also play roles in axon navigation, midline guidance in the forebrain, and neuronal cell migration.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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