Rap1/Ran GTPase-activating
IPR050989
Definition
The protein family is involved in the regulation of GTPase activity for nuclear Ras-related regulatory proteins such as Rap1, Rap2, and Ran, typically converting them to an inactive GDP-bound state. Members of the family play key roles in various cellular processes including cell cycle progression, epithelial cell morphogenesis, polarity, adhesion, cytoskeletal organization, and dendritic spine morphogenesis. They are also implicated in the regulation of cell adhesion and chemotaxis by controlling myosin II assembly and disassembly. The family contributes to the spatial and temporal regulation of these processes, which are crucial for proper cell function and development.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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