Seroatlas · Human Serome Atlas

RAP1GAP2

Rap1 GTPase-activating protein 2

Also known as: GARNL4, KIAA1039, RPGP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q684P5
Gene
RAP1GAP2
Ensembl
ENSG00000132359
Chromosome
17
Canonical length
730 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear membrane,Cytosol,Perinuclear theca,Flagellar centriole,Principal piece

OverviewNCBI Gene

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

730 residues, UniProt reviewed canonical sequence.

>Q684P5|RAP1GAP2
     1  MFGRKRSVSF GGFGWIDKTM LASLKVKKQE LANSSDATLP DRPLSPPLTA PPTMKSSEFF
    61  EMLEKMQGIK LEEQKPGPQK NKDDYIPYPS IDEVVEKGGP YPQVILPQFG GYWIEDPENV
   121  GTPTSLGSSI CEEEEEDNLS PNTFGYKLEC KGEARAYRRH FLGKDHLNFY CTGSSLGNLI
   181  LSVKCEEAEG IEYLRVILRS KLKTVHERIP LAGLSKLPSV PQIAKAFCDD AVGLRFNPVL
   241  YPKASQMIVS YDEHEVNNTF KFGVIYQKAR QTLEEELFGN NEESPAFKEF LDLLGDTITL
   301  QDFKGFRGGL DVTHGQTGVE SVYTTFRDRE IMFHVSTKLP FTDGDAQQLQ RKRHIGNDIV
   361  AIIFQEENTP FVPDMIASNF LHAYIVVQVE TPGTETPSYK VSVTAREDVP TFGPPLPSPP
   421  VFQKGPEFRE FLLTKLTNAE NACCKSDKFA KLEDRTRAAL LDNLHDELHA HTQAMLGLGP
   481  EEDKFENGGH GGFLESFKRA IRVRSHSMET MVGGQKKSHS GGIPGSLSGG ISHNSMEVTK
   541  TTFSPPVVAA TVKNQSRSPI KRRSGLFPRL HTGSEGQGDS RARCDSTSST PKTPDGGHSS
   601  QEIKSETSSN PSSPEICPNK EKPFMKLKEN GRAISRSSSS TSSVSSTAGE GEAMEEGDSG
   661  GSQPSTTSPF KQEVFVYSPS PSSESPSLGA AATPIIMSRS PTDAKSRNSP RSNLKFRFDK
   721  LSHASSGAGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAP1GAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 37 nTPM
  • bone marrow: 26 nTPM
  • stomach: 22 nTPM
  • cerebellum: 21 nTPM
  • cerebral cortex: 20 nTPM
  • heart muscle: 14 nTPM

Single-cell type

  • neutrophils: 916 nCPM
  • retinal ganglion cells: 634 nCPM
  • thymocytes: 446 nCPM
  • neuroendocrine cells: 431 nCPM
  • neutrophil progenitors: 413 nCPM
  • pancreatic islet cells: 386 nCPM

Immune cell

  • neutrophil: 4.2 nTPM
  • non-classical monocyte: 3.9 nTPM
  • gdT-cell: 2.8 nTPM
  • intermediate monocyte: 2.7 nTPM
  • eosinophil: 2.1 nTPM
  • memory CD8 T-cell: 2.1 nTPM

Brain region

  • cerebral cortex: 100 nTPM
  • white matter: 88 nTPM
  • basal ganglia: 77 nTPM
  • hippocampal formation: 60 nTPM
  • cerebellum: 60 nTPM
  • amygdala: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
2.23
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAP1GAP2 as an antibody target. Whether an autoantibody or antibody against RAP1GAP2 could matter depends on whether native RAP1GAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAP1GAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAP1GAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAP1GAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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