Seroatlas · Human Serome Atlas

GARNL3

GTPase-activating Rap/Ran-GAP domain-like protein 3

Also known as: bA356B19.1, DKFZp761J1523, GARL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VVW2
Gene: GARNL3
Ensembl: ENSG00000136895
Chromosome: 9
Canonical length: 1013 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1013 residues, UniProt reviewed canonical sequence.

>Q5VVW2|GARNL3
     1  MVVDFCRRFV ARSLCIILMK HFCSSSVSED LGCRRGDFSR KHYGSVELLI SSDADGAIQR
    61  AGRFRVENGS SDENATALPG TWRRTDVHLE NPEYHTRWYF KYFLGQVHQN YIGNDAEKSP
   121  FFLSVTLSDQ NNQRVPQYRA ILWRKTGTQK ICLPYSPTKT LSVKSILSAM NLDKFEKGPR
   181  EIFHPEIQKD LLVLEEQEGS VNFKFGVLFA KDGQLTDDEM FSNEIGSEPF QKFLNLLGDT
   241  ITLKGWTGYR GGLDTKNDTT GIHSVYTVYQ GHEIMFHVST MLPYSKENKQ QVERKRHIGN
   301  DIVTIVFQEG EESSPAFKPS MIRSHFTHIF ALVRYNQQND NYRLKIFSEE SVPLFGPPLP
   361  TPPVFTDHQE FRDFLLVKLI NGEKATLETP TFAQKRRRTL DMLIRSLHQD LMPDLHKNML
   421  NRRSFSDVLP ESPKSARKKE EARQAEFVRI GQALKLKSIV RGDAPSSLAA SGICKKEPWE
   481  PQCFCSNFPH EAVCADPWGQ ALLVSTDAGV LLVDDDLPSV PVFDRTLPVK QMHVLETLDL
   541  LVLRADKGKD ARLFVFRLSA LQKGLEGKQA GKSRSDCREN KLEKTKGCHL YAINTHHSRE
   601  LRIVVAIRNK LLLITRKHNK PSGVTSTSLL SPLSESPVEE FQYIREICLS DSPMVMTLVD
   661  GPAEESDNLI CVAYRHQFDV VNESTGEAFR LHHVEANRVN FVAAIDVYED GEAGLLLCYN
   721  YSCIYKKVCP FNGGSFLVQP SASDFQFCWN QAPYAIVCAF PYLLAFTTDS MEIRLVVNGN
   781  LVHTAVVPQL QLVASRSDIY FTATAAVNEV SSGGSSKGAS ARNSPQTPPG RDTPVFPSSL
   841  GEGEIQSKNL YKIPLRNLVG RSIERPLKSP LVSKVITPPT PISVGLAAIP VTHSLSLSRM
   901  EIKEIASRTR RELLGLSDEG GPKSEGAPKA KSKPRKRLEE SQGGPKPGAV RSSSSDRIPS
   961  GSLESASTSE ANPEGHSASS DQDPVADREG SPVSGSSPFQ LTAFSDEDII DLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GARNL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 20 nTPM
blood vessel: 19 nTPM
cerebral cortex: 12 nTPM
heart muscle: 11 nTPM
amygdala: 10 nTPM
endometrium: 9 nTPM

Single-cell type

adrenal medulla cells: 266 nCPM
endometrial stromal cells: 236 nCPM
cardiomyocytes: 221 nCPM
astrocytes: 221 nCPM
oligodendrocytes: 208 nCPM
brain excitatory neurons: 204 nCPM

Immune cell

plasmacytoid DC: 1 nTPM
gdT-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

cerebellum: 34 nTPM
white matter: 32 nTPM
cerebral cortex: 24 nTPM
pons: 22 nTPM
basal ganglia: 21 nTPM
hypothalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GARNL3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 129 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0
gnomAD missense Z: 2.02
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of small GTPase mediated signal transduction

Molecular functions

GTPase activator activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GARNL3 as an antibody target. Whether an autoantibody or antibody against GARNL3 could matter depends on whether native GARNL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GARNL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GARNL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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