Collagen-modifying Glycosyltransferase 25
IPR050757
Definition
The glycosyltransferase 25 family is involved in the post-translational modification of collagen, a structural protein essential for the integrity of various tissues. Family members include enzymes that hydroxylate lysine residues within collagen sequences, which is a prerequisite for the subsequent glycosylation of these residues. The hydroxylysine sites serve as attachment points for carbohydrate units, crucial for collagen fibril assembly, cross-linking, and stability. Some members exhibit multifunctional activities, catalyzing both hydroxylation and glycosylation, contributing to the formation of the collagen triple helix and the biosynthesis of different collagen types, including type I and IV. Others are involved in cell adhesion processes. The family also includes proteins that, despite sharing sequence similarity, are inactive as glycosyltransferases and may have divergent functions.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...