Seroatlas · Human Serome Atlas

COLGALT2

Procollagen galactosyltransferase 2

Also known as: C1orf17, GLT25D2, GT252_HUMAN, KIAA0584

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYK4
Gene: COLGALT2
Ensembl: ENSG00000198756
Chromosome: 1
Canonical length: 626 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable procollagen galactosyltransferase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q8IYK4|COLGALT2
     1  MAARPAATLA WSLLLLSSAL LREGCRARFV AERDSEDDGE EPVVFPESPL QSPTVLVAVL
    61  ARNAAHTLPH FLGCLERLDY PKSRMAIWAA TDHNVDNTTE IFREWLKNVQ RLYHYVEWRP
   121  MDEPESYPDE IGPKHWPTSR FAHVMKLRQA ALRTAREKWS DYILFIDVDN FLTNPQTLNL
   181  LIAENKTIVA PMLESRGLYS NFWCGITPKG FYKRTPDYVQ IREWKRTGCF PVPMVHSTFL
   241  IDLRKEASDK LTFYPPHQDY TWTFDDIIVF AFSSRQAGIQ MYLCNREHYG YLPIPLKPHQ
   301  TLQEDIENLI HVQIEAMIDR PPMEPSQYVS VVPKYPDKMG FDEIFMINLK RRKDRRDRML
   361  RTLYEQEIEV KIVEAVDGKA LNTSQLKALN IEMLPGYRDP YSSRPLTRGE IGCFLSHYSV
   421  WKEVIDRELE KTLVIEDDVR FEHQFKKKLM KLMDNIDQAQ LDWELIYIGR KRMQVKEPEK
   481  AVPNVANLVE ADYSYWTLGY VISLEGAQKL VGANPFGKML PVDEFLPVMY NKHPVAEYKE
   541  YYESRDLKAF SAEPLLIYPT HYTGQPGYLS DTETSTIWDN ETVATDWDRT HAWKSRKQSR
   601  IYSNAKNTEA LPPPTSLDTV PSRDEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COLGALT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 26 nTPM
cerebral cortex: 26 nTPM
hippocampal formation: 15 nTPM
midbrain: 15 nTPM
cerebellum: 13 nTPM
basal ganglia: 11 nTPM

Single-cell type

oligodendrocytes: 415 nCPM
oligodendrocyte progenitor cells: 178 nCPM
fibro-adipogenic progenitors: 128 nCPM
adrenal medulla cells: 117 nCPM
late spermatids: 106 nCPM
early spermatids: 71 nCPM

Immune cell

basophil: 11 nTPM
gdT-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

white matter: 114 nTPM
basal ganglia: 72 nTPM
pons: 72 nTPM
medulla oblongata: 71 nTPM
thalamus: 66 nTPM
midbrain: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COLGALT2 as an antibody target. Whether an autoantibody or antibody against COLGALT2 could matter depends on whether native COLGALT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COLGALT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COLGALT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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