Seroatlas · Human Serome Atlas

CERCAM

Inactive glycosyltransferase 25 family member 3

Also known as: CEECAM1, GLT25D3, GT253_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T4B2
Gene: CERCAM
Ensembl: ENSG00000167123
Chromosome: 9
Canonical length: 595 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cell Junctions
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables identical protein binding activity. Acts upstream of or within cell adhesion. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>Q5T4B2|CERCAM
     1  MRAARAAPLL QLLLLLGPWL EAAGVAESPL PAVVLAILAR NAEHSLPHYL GALERLDYPR
    61  ARMALWCATD HNVDNTTEML QEWLAAVGDD YAAVVWRPEG EPRFYPDEEG PKHWTKERHQ
   121  FLMELKQEAL TFARNWGADY ILFADTDNIL TNNQTLRLLM GQGLPVVAPM LDSQTYYSNF
   181  WCGITPQGYY RRTAEYFPTK NRQRRGCFRV PMVHSTFLAS LRAEGADQLA FYPPHPNYTW
   241  PFDDIIVFAY ACQAAGVSVH VCNEHRYGYM NVPVKSHQGL EDERVNFIHL ILEALVDGPR
   301  MQASAHVTRP SKRPSKIGFD EVFVISLARR PDRRERMLAS LWEMEISGRV VDAVDGWMLN
   361  SSAIRNLGVD LLPGYQDPYS GRTLTKGEVG CFLSHYSIWE EVVARGLARV LVFEDDVRFE
   421  SNFRGRLERL MEDVEAEKLS WDLIYLGRKQ VNPEKETAVE GLPGLVVAGY SYWTLAYALR
   481  LAGARKLLAS QPLRRMLPVD EFLPIMFDQH PNEQYKAHFW PRDLVAFSAQ PLLAAPTHYA
   541  GDAEWLSDTE TSSPWDDDSG RLISWSGSQK TLRSPRLDLT GSSGHSLQPQ PRDEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CERCAM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 437 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 437 nTPM
hippocampal formation: 360 nTPM
midbrain: 324 nTPM
basal ganglia: 322 nTPM
amygdala: 204 nTPM
hypothalamus: 183 nTPM

Single-cell type

oligodendrocytes: 679 nCPM
somatotrophs: 247 nCPM
thyrotrophs: 226 nCPM
hepatic stellate cells: 149 nCPM
lactotrophs: 109 nCPM
extravillous trophoblasts: 95 nCPM

Immune cell

naive CD8 T-cell: 2.2 nTPM
memory CD8 T-cell: 2 nTPM
gdT-cell: 1.7 nTPM
total PBMC: 1.2 nTPM
plasmacytoid DC: 1 nTPM
myeloid DC: 0.7 nTPM

Brain region

white matter: 867 nTPM
cerebral cortex: 642 nTPM
basal ganglia: 602 nTPM
thalamus: 551 nTPM
midbrain: 476 nTPM
medulla oblongata: 467 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CERCAM as an antibody target. Whether an autoantibody or antibody against CERCAM could matter depends on whether native CERCAM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CERCAM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CERCAM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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