Seroatlas · Human Serome Atlas

FSTL5

Follistatin-related protein 5

Also known as: DKFZp566D234, FSTL5_HUMAN, KIAA1263

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N475
Gene: FSTL5
Ensembl: ENSG00000168843
Chromosome: 4
Canonical length: 847 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation and regulation of BMP signaling pathway. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

847 residues, UniProt reviewed canonical sequence.

>Q8N475|FSTL5
     1  MFKCWSVVLV LGFIFLESEG RPTKEGGYGL KSYQPLMRLR HKQEKNQESS RVKGFMIQDG
    61  PFGSCENKYC GLGRHCVTSR ETGQAECACM DLCKRHYKPV CGSDGEFYEN HCEVHRAACL
   121  KKQKITIVHN EDCFFKGDKC KTTEYSKMKN MLLDLQNQKY IMQENENPNG DDISRKKLLV
   181  DQMFKYFDAD SNGLVDINEL TQVIKQEELG KDLFDCTLYV LLKYDDFNAD KHLALEEFYR
   241  AFQVIQLSLP EDQKLSITAA TVGQSAVLSC AIQGTLRPPI IWKRNNIILN NLDLEDINDF
   301  GDDGSLYITK VTTTHVGNYT CYADGYEQVY QTHIFQVNVP PVIRVYPESQ AREPGVTASL
   361  RCHAEGIPKP QLGWLKNGID ITPKLSKQLT LQANGSEVHI SNVRYEDTGA YTCIAKNEAG
   421  VDEDISSLFV EDSARKTLAN ILWREEGLGI GNMFYVFYED GIKVIQPIEC EFQRHIKPSE
   481  KLLGFQDEVC PKAEGDEVQR CVWASAVNVK DKFIYVAQPT LDRVLIVDVQ SQKVVQAVST
   541  DPVPVKLHYD KSHDQVWVLS WGTLEKTSPT LQVITLASGN VPHHTIHTQP VGKQFDRVDD
   601  FFIPTTTLII THMRFGFILH KDEAALQKID LETMSYIKTI NLKDYKCVPQ SLAYTHLGGY
   661  YFIGCKPDST GAVSPQVMVD GVTDSVIGFN SDVTGTPYVS PDGHYLVSIN DVKGLVRVQY
   721  ITIRGEIQEA FDIYTNLHIS DLAFQPSFTE AHQYNIYGSS STQTDVLFVE LSSGKVKMIK
   781  SLKEPLKAEE WPWNRKNRQI QDSGLFGQYL MTPSKDSLFI LDGRLNKLNC EITEVEKGNT
   841  VIWVGDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSTL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

retina: 88 nTPM
cerebellum: 45 nTPM
cerebral cortex: 9.4 nTPM
hypothalamus: 7.3 nTPM
basal ganglia: 6.2 nTPM
adrenal gland: 5.7 nTPM

Single-cell type

cone photoreceptor cells: 2,644 nCPM
retinal bipolar cells: 1,994 nCPM
brain excitatory neurons: 1,053 nCPM
rod photoreceptor cells: 828 nCPM
bergmann glia: 661 nCPM
corticotrophs: 594 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 152 nTPM
hypothalamus: 40 nTPM
pons: 36 nTPM
midbrain: 27 nTPM
medulla oblongata: 25 nTPM
basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSTL5 as an antibody target. Whether an autoantibody or antibody against FSTL5 could matter depends on whether native FSTL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSTL5 is annotated as secreted, so native FSTL5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FSTL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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