Flavin-containing monooxygenases-like
IPR050346
Definition
The FMO family comprises flavin-containing monooxygenases that play a crucial role in the metabolism of a wide array of nitrogen- and sulfur-containing compounds, including xenobiotics, drugs, and dietary components. Members of this family are involved in the detoxification of trimethylamine (TMA), converting it to trimethylamine N-oxide (TMAO), a process influenced by gut microbiota from dietary precursors such as choline and carnitine PMID:27997715. This reaction is significant for regulating TMAO concentration, impacting platelet responsiveness and thrombus formation. Additionally, the family includes enzymes that catalyse the conversion of methylthioalkyl glucosinolates into methylsulfinylalkyl glucosinolates, and the oxidation of various other substrates, indicating a broad substrate specificity. Some members are also involved in the biosynthesis of secondary metabolites and pigments, as well as the oxidative metabolism of therapeutic drugs and insecticides. This entry also includes 4-hydroxybenzoate brominase that catalyses the bromination of 4-hydroxybenzoate (4-HBA) to 3-bromo-4-hydroxybenzoate, followed by bromination and decarboxylation of 3-bromo-4-hydroxybenzoate to 2,4-dibromophenol PMID:25061970. The family's functions are essential for various physiological processes, including correct protein folding, cholesterol biosynthesis, glucose homeostasis, and systemic acquired resistance in plants.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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