FMO1

Protein identityUniProt · HPA

UniProt accession

Q01740

Gene

FMO1

Ensembl

ENSG00000010932

Chromosome

1

Canonical length

532 aa

Protein class

Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

532 residues, UniProt reviewed canonical sequence.

>Q01740|FMO1
     1  MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG RASLYKSVVS
    61  NSCKEMSCYS DFPFPEDYPN YVPNSQFLEY LKMYANHFDL LKHIQFKTKV CSVTKCSDSA
   121  VSGQWEVVTM HEEKQESAIF DAVMVCTGFL TNPYLPLDSF PGINAFKGQY FHSRQYKHPD
   181  IFKDKRVLVI GMGNSGTDIA VEASHLAEKV FLSTTGGGWV ISRIFDSGYP WDMVFMTRFQ
   241  NMLRNSLPTP IVTWLMERKI NNWLNHANYG LIPEDRTQLK EFVLNDELPG RIITGKVFIR
   301  PSIKEVKENS VIFNNTSKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA SLYKYIFPAH
   361  LQKPTLAIIG LIKPLGSMIP TGETQARWAV RVLKGVNKLP PPSVMIEEIN ARKENKPSWF
   421  GLCYCKALQS DYITYIDELL TYINAKPNLF SMLLTDPHLA LTVFFGPCSP YQFRLTGPGK
   481  WEGARNAIMT QWDRTFKVIK ARVVQESPSP FESFLKVFSF LALLVAIFLI FL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FMO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

186 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.09

gnomAD pLI

0

gnomAD missense Z

1.05

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• energy homeostasis
• negative regulation of fatty acid oxidation
• organic acid metabolic process
• response to lipopolysaccharide
• sulfur amino acid catabolic process
• taurine biosynthetic process
• toxin metabolic process
• xenobiotic metabolic process

Molecular functions

• flavin adenine dinucleotide binding
• hypotaurine monooxygenase activity
• monooxygenase activity
• N,N-dimethylaniline monooxygenase activity
• NADP binding
• trimethylamine monooxygenase activity

Cellular components

• endoplasmic reticulum lumen
• endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

• Flavin monooxygenase FMO
• Flavin monooxygenase-like
• FAD/NAD(P)-binding domain superfamily
• Flavin-containing monooxygenases-like
• Flavin-binding monooxygenase-like
• Flavin monooxygenase (FMO) 1

KeywordsUniProt

• Acetylation
• Endoplasmic reticulum
• FAD
• Flavoprotein
• Membrane
• Monooxygenase
• NADP
• Oxidoreductase
• Transmembrane
• Transmembrane helix