Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily

Definition

Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. Regulating the activity of the branched-chain alpha-ketoacid dehydrogenase (BCDH) complex is the primary means by which these processes are coordinated. BCDH kinase regulates BCDH by phosphorylation, thereby inactivating it when synthesis is required. The N-terminal domain of the alpha-ketoacid dehydrogenase kinase has a bromodomain-like fold, which consists of four helices arranged in bundle with minor mirror variant of up-and-down topology.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• BCKDK
• PDK1
• PDK2
• PDK3
• PDK4