Seroatlas · Human Serome Atlas

SLC25A42

Mitochondrial coenzyme A transporter SLC25A42

Also known as: MGC26694, S2542_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VD7
Gene
SLC25A42
Ensembl
ENSG00000181035
Chromosome
19
Canonical length
318 aa
Protein class
Disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q86VD7|SLC25A42
     1  MGNGVKEGPV RLHEDAEAVL SSSVSSKRDH RQVLSSLLSG ALAGALAKTA VAPLDRTKII
    61  FQVSSKRFSA KEAFRVLYYT YLNEGFLSLW RGNSATMVRV VPYAAIQFSA HEEYKRILGS
   121  YYGFRGEALP PWPRLFAGAL AGTTAASLTY PLDLVRARMA VTPKEMYSNI FHVFIRISRE
   181  EGLKTLYHGF MPTVLGVIPY AGLSFFTYET LKSLHREYSG RRQPYPFERM IFGACAGLIG
   241  QSASYPLDVV RRRMQTAGVT GYPRASIART LRTIVREEGA VRGLYKGLSM NWVKGPIAVG
   301  ISFTTFDLMQ ILLRHLQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • liver: 76 nTPM
  • skeletal muscle: 43 nTPM
  • kidney: 32 nTPM
  • tongue: 30 nTPM
  • thyroid gland: 23 nTPM
  • cerebellum: 19 nTPM

Single-cell type

  • myonuclei: 183 nCPM
  • proximal tubule cells: 182 nCPM
  • retinal bipolar cells: 111 nCPM
  • hepatocytes: 89 nCPM
  • rod photoreceptor cells: 78 nCPM
  • retinal ganglion cells: 73 nCPM

Immune cell

  • memory B-cell: 3.3 nTPM
  • naive B-cell: 3.2 nTPM
  • gdT-cell: 2.8 nTPM
  • memory CD8 T-cell: 2.4 nTPM
  • NK-cell: 1.8 nTPM
  • T-reg: 1.7 nTPM

Brain region

  • hypothalamus: 24 nTPM
  • hippocampal formation: 24 nTPM
  • cerebral cortex: 23 nTPM
  • amygdala: 22 nTPM
  • thalamus: 22 nTPM
  • choroid plexus: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC25A42.

Disease | AllUniProt

Conditions SLC25A42 is implicated in, by any mechanism.

  • Metabolic crises, recurrent, with variable encephalomyopathic features and neurologic regression (MECREN) MIM:618416

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 206 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.49
gnomAD missense Z
2.1
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A42 as an antibody target. Whether an autoantibody or antibody against SLC25A42 could matter depends on whether native SLC25A42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC25A42. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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