KIND domain

Definition

The KIND (kinase non-catalytic C-lobe domain) is a putative protein interaction domain, which has been identified as being similar to the C-terminal protein kinase catalytic fold (C lobe) (see [prositedoc:PDOC00100]). The presence of the KIND domain at the N terminus of signalling proteins and the absence of the active site residues in the catalytic and activation loops suggest that it folds independently and is likely to be non-catalytic. The occurrence of the domain only in metazoa implies that it has evolved from the catalytic protein kinase domain into an interaction domain possibly by keeping the substrate-binding features [[cite:PMID:12877999], [cite:PMID:16099729]]. In SPIRE1 (protein spire homologue 1) this domain interacts with FMN2 (formin-2) [[cite:PMID:21730168], [cite:PMID:21705804]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• FRMPD2
• KNDC1
• PTPN13
• SPIRE1
• SPIRE2