Seroatlas · Human Serome Atlas

SPIRE2

Protein spire homolog 2

Also known as: KIAA1832, spir-2, SPIR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WWL2
Gene
SPIRE2
Ensembl
ENSG00000204991
Chromosome
16
Canonical length
714 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Intermediate filaments

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Involved in establishment of meiotic spindle localization; formin-nucleated actin cable assembly; and positive regulation of double-strand break repair. Predicted to be located in cleavage furrow. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

714 residues, UniProt reviewed canonical sequence.

>Q8WWL2|SPIRE2
     1  MARAGSCGGA AAGAGRPEPW ELSLEEVLKA YEQPLNEEQA WAVCFQGCRG LRGSPGRRLR
    61  DTGDLLLRGD GSVGAREPEA AEPATMVVPL ASSEAQTVQS LGFAIYRALD WGLDESEERE
   121  LSPQLERLID LMANNDSEDS GCGAADEGYG GPEEEEEAEG VPRSVRTFAQ AMRLCAARLT
   181  DPRGAQAHYQ AVCRALFVET LELRAFLARV REAKEMLQKL REDEPHLETP RAELDSLGHT
   241  DWARLWVQLM RELRRGVKLK KVQEQEFNPL PTEFQLTPFE MLMQDIRARN YKLRKVMVDG
   301  DIPPRVKKDA HELILDFIRS RPPLKQVSER RLRPLPPKQR SLHEKILEEI KQERRLRPVR
   361  GEGWAARGFG SLPCILNACS GDAKSTSCIN LSVTDAGGSA QRPRPRVLLK APTLAEMEEM
   421  NTSEEEESPC GEVTLKRDRS FSEHDLAQLR SEVASGLQSA THPPGGTEPP RPRAGSAHVW
   481  RPGSRDQGTC PASVSDPSHP LLSNRGSSGD RPEASMTPDA KHLWLEFSHP VESLALTVEE
   541  VMDVRRVLVK AEMEKFLQNK ELFSSLKKGK ICCCCRAKFP LFSWPPSCLF CKRAVCTSCS
   601  IKMKMPSKKF GHIPVYTLGF ESPQRVSAAK TAPIQRRDIF QSLQGPQWQS VEEAFPHIYS
   661  HGCVLKDVCS ECTSFVADVV RSSRKSVDVL NTTPRRSRQT QSLYIPNTRT LDFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPIRE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 25 nTPM
  • pituitary gland: 21 nTPM
  • colon: 15 nTPM
  • cerebral cortex: 15 nTPM
  • stomach: 14 nTPM
  • basal ganglia: 12 nTPM

Single-cell type

  • somatotrophs: 214 nCPM
  • syncytiotrophoblasts: 148 nCPM
  • foveolar cells: 142 nCPM
  • prostatic club cells: 141 nCPM
  • prostatic hillock cells: 132 nCPM
  • urothelial cells: 132 nCPM

Immune cell

  • basophil: 2.3 nTPM
  • neutrophil: 1.9 nTPM
  • naive B-cell: 0.7 nTPM
  • NK-cell: 0.6 nTPM
  • classical monocyte: 0.5 nTPM
  • memory B-cell: 0.5 nTPM

Brain region

  • cerebral cortex: 30 nTPM
  • cerebellum: 29 nTPM
  • pons: 26 nTPM
  • medulla oblongata: 23 nTPM
  • basal ganglia: 23 nTPM
  • midbrain: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
-0.26
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPIRE2 as an antibody target. Whether an autoantibody or antibody against SPIRE2 could matter depends on whether native SPIRE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPIRE2 is annotated at the cell surface, where native SPIRE2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SPIRE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPIRE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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