Seroatlas · Human Serome Atlas

KNDC1

Kinase non-catalytic C-lobe domain-containing protein 1

Also known as: bB439H18.3, C10orf23, FLJ25027, KIAA1768, KNDC1_HUMAN, RASGEF2, v-KIND, Very-KIND

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q76NI1
Gene: KNDC1
Ensembl: ENSG00000171798
Chromosome: 10
Canonical length: 1749 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

1749 residues, UniProt reviewed canonical sequence.

>Q76NI1|KNDC1
     1  MQAMDPAAAD LYEEDGKDLD FYDFEPLPTL PEDEENVSLA DILSLRDRGL SEQEAWAVCL
    61  ECSLSMRSVA HAAIFQSLCI TPDTLAFNTS GNVCFMEQLS DDPEGAFVPP EFDVTGNTFE
   121  AHIYSLGATL KAALEYVAEP TLEPRLSQDL EALLSRMQAE DPGDRPDLES IIALCEEKLQ
   181  LTSSCRVCRS LSAVGRRVLS IESFGALQDV SESSWRERPA PGNAGPRRPP GDPSTDPEVL
   241  PTPEGPESET SRGPRASPTK ALLSTPVRNG ESHSREGLAG LVLDAERTLG ELDRDALRRS
   301  RLRKVQTFPR LLSDSPEATL CLPLTRGKSQ LPISELFSPD PRKAFLDRKN GLSSFQAQPK
   361  CRLWPEQEPE HQLGRVPCAG RSTDRGPGVP GSPGQPETSH PSQGPAEAPA DPRDASGEAQ
   421  TPRDDERIPE GARQLESAAA EQWVSLQDLL SQLGRPFREY ELWALCLACL RALQTRPEHP
   481  AYLCLDSVLV AEDGAVLFQP PPANGSYDSF FLAPELAEER LVTEKASVYC VAAVLWTAAK
   541  FSVPRNHKLA LPRRLKTLLL DMARRSAPER PSAAEAIKVC GSYLLQRGMD SRKILAHLRA
   601  SICQVYQEEE TISLQNAFSV VELKPSVAPA PEPSPGFLPV NSDTGLVAVP GPVPGQHPCG
   661  EEATQLPAAF TSEATHFKPI VLAQNASVAR DQPALAQEES EERGGQREGE GEEKLSLEAH
   721  AGSPSLKTPD GPVPGPGPQG AAPEPLGASV QRDSAQGRPC PPPQAPANQP EGASSAAPGS
   781  PVPAPPTKAS ALPVEQGPAE PIPPGVASGG LRPDALGPTT AHHGPRHPPK PPRSKATERP
   841  GQEPEGPGAT PAGERDDQSP DSVPERPRPA DRRLCLPCVD ASPLPGRTAC PSLQEATRLI
   901  QEEFAFDGYL DNGLEALIMG EYIFALKDLT FATFCGAISE KFCDLYWDEK LLQNLFKVVN
   961  GQASPSPSTA EEAGSQLEGS QSPRSPSSKR PSLHRLGKEK PAMARTSSRA PCSPTSVSDV
  1021  DSDALSRGNF EVGFRPQRSV KAERAQQPEA GEDRRPAGGA SDVEAVTRLA RSKGVGPALS
  1081  PGPAGFQSCS PGWCSAFYEA DCFGADVHNY VKDLGRQQAD GALPDAQSPE LEQQLMMEKR
  1141  NYRKTLKFYQ KLLQKEKRNK GSDVKTMLSK LKGQLEEMKS RVQFLSLVKK YLQVMYAERW
  1201  GLEPCTLPVI VNIAAAPCDT LDFSPLDESS SLIFYNVNKH PGGRQKARIL QAGTPLGLMA
  1261  YLYSSDAFLE GYVQQFLYTF RYFCTPHDFL HFLLDRINST LTRAHQDPTS TFTKIYRRSL
  1321  CVLQAWVEDC YAVDFPRNSG LLGKLEDFIS SKILPLDGSA KHLLGLLEVG MDRRAEGNPR
  1381  GTDLENPREA EEDARPFNAL CKRLSEDGIS RKSFPWRLPR GNGLVLPPHK ERPYTIAAAL
  1441  PKPCFLEDFY GPCAKTSEKG PYFLTEYSTH QLFSQLTLLQ QELFQKCHPV HFLNSRALGV
  1501  MDKSTAIPKA SSSESLSAKT CSLFLPNYVQ DKYLLQLLRN ADDVSTWVAA EIVTSHTSKL
  1561  QVNLLSKFLL IAKSCYEQRN FATAMQILSG LEHLAVRQSP AWRILPAKIA EVMEELKAVE
  1621  VFLKSDSLCL MEGRRFRAQP TLPSAHLLAM HIQQLETGGF TMTNGAHRWS KLRNIAKVVS
  1681  QVHAFQENPY TFSPDPKLQS YLKQRIARFS GADISTLAAD SRANFHQVSS EKHSRKIQDK
  1741  LRRMKATFQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KNDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 42 nTPM
cerebral cortex: 39 nTPM
amygdala: 28 nTPM
pituitary gland: 24 nTPM
hippocampal formation: 23 nTPM
hypothalamus: 22 nTPM

Single-cell type

ependymal cells: 188 nCPM
astrocytes: 162 nCPM
somatotrophs: 148 nCPM
gonadotrophs: 135 nCPM
corticotrophs: 125 nCPM
respiratory ciliated cells: 109 nCPM

Immune cell

non-classical monocyte: 1.1 nTPM
basophil: 0.6 nTPM
intermediate monocyte: 0.6 nTPM
neutrophil: 0.4 nTPM
classical monocyte: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebral cortex: 167 nTPM
amygdala: 134 nTPM
thalamus: 113 nTPM
hippocampal formation: 101 nTPM
cerebellum: 100 nTPM
white matter: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ras-like guanine nucleotide exchange factor, N-terminal
Ras guanine-nucleotide exchange factors catalytic domain
Protein kinase-like domain superfamily
KIND domain
Ras guanine nucleotide exchange factor domain superfamily
Ras guanine-nucleotide exchange factor, catalytic domain superfamily
RasGEF domain
RasGEF N-terminal motif
Kinase non-catalytic C-lobe domain
Kinase non-catalytic C-lobe domain-containing protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KNDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KNDC1 as an antibody target. Whether an autoantibody or antibody against KNDC1 could matter depends on whether native KNDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KNDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KNDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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