DNA-binding RFX-type winged-helix domain

Definition

The RFX family of transcription factors is characterised by a unique approximately 75-residue DNA-binding domain. RFX genes have been isolated in yeasts, nematode and vertebrates. The characteristic RFX-type HTH DNA binding domain has been recruited into otherwise very divergent regulatory factors functioning in a diverse spectrum of unrelated systems, including regulation of the mitotic cell cycle in fission yeast, the control of the immune response in mammals and infection by human hepatitis B virus [[cite:PMID:8600444], [cite:PMID:10767550]].

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• ARID2
• RFX1
• RFX2
• RFX3
• RFX4
• RFX5
• RFX6
• RFX7
• RFX8