Seroatlas · Human Serome Atlas

ZNF85

Zinc finger protein 85

Also known as: HPF4, HTF1, ZNF85_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03923
Gene
ZNF85
Ensembl
ENSG00000105750
Chromosome
19
Canonical length
595 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>Q03923|ZNF85
     1  MGPLTFRDVA IEFSLKEWQC LDTAQRNLYR NVMLENYRNL VFLGITVSKP DLITCLEQGK
    61  EAWSMKRHEI MVAKPTVMCS HFAQDLWPEQ NIKDSFQKVT LKRYGKCRHE NLPLRKGCES
   121  MDECKMHKGG CNGLNQCLTA TQSKIFQCDK YVKVAHKFSN SNRHEIRHTK KKPFKCTKCG
   181  KSFGMISCLT EHSRIHTRVN FYKCEECGKA FNWSSTLTKH KRIHTGEKPY KCEECGKAFN
   241  QSSNLIKHKK IHTGEKPYKC EECGKTFNRF STLTTHKIIH TGEKPYKCKE CGKAFNRSST
   301  LTTHRKIHTG EKPYKCEECG KAFKQSSNLT THKIIHTGEK PYKCKKCGKA FNQSAHLTTH
   361  EVIHTGEKPY KCEKCGKAFN HFSHLTTHKI IHTGEKPYKC KECGKAFKHS STLTKHKIIH
   421  TGEKPYKCKE CEKAFNQSSK LTEHKKIHTG EKPYECEKCG KAFNQSSNLT RHKKSHTEEK
   481  PYKCEECGKG FKWPSTLTIH KIIHTGEKPY KCEECGKAFN QSSKLTKHKK IHTGEKPYTC
   541  EECGKAFNQS SNLTKHKRIH TGEKPYKCEE CDKAFKWSSV LTKHKIIHTG EKLQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF85 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • testis: 10 nTPM
  • pancreas: 7.2 nTPM
  • thyroid gland: 7.2 nTPM
  • ovary: 6.8 nTPM
  • tonsil: 5.6 nTPM
  • lymph node: 5.3 nTPM

Single-cell type

  • microglia: 19 nCPM
  • distal convoluted tubule cells: 18 nCPM
  • oligodendrocyte progenitor cells: 17 nCPM
  • renal collecting duct intercalated cells: 15 nCPM
  • renal collecting duct principal cells: 15 nCPM
  • renal connecting tubule cells: 13 nCPM

Immune cell

  • memory B-cell: 5.4 nTPM
  • NK-cell: 5.3 nTPM
  • naive B-cell: 3.6 nTPM
  • eosinophil: 2.8 nTPM
  • T-reg: 2.8 nTPM
  • naive CD4 T-cell: 2.6 nTPM

Brain region

  • cerebellum: 9.8 nTPM
  • white matter: 5.8 nTPM
  • medulla oblongata: 5.3 nTPM
  • midbrain: 5.3 nTPM
  • pons: 5.2 nTPM
  • cerebral cortex: 5.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF85.

Disease | AutoantibodyPubMed

Conditions in which antibodies against ZNF85 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for ZNF85 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

14 publications

Show 9 more

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0
gnomAD missense Z
-1.45
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF85 as an antibody target. Whether an autoantibody or antibody against ZNF85 could matter depends on whether native ZNF85 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF85 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF85 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF85. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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