Seroatlas · Human Serome Atlas

ZNF846

Zinc finger protein 846

Also known as: ZN846_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q147U1
Gene: ZNF846
Ensembl: ENSG00000196605
Chromosome: 19
Canonical length: 533 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Actin filaments

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

533 residues, UniProt reviewed canonical sequence.

>Q147U1|ZNF846
     1  MDSSQHLVTF EDVAVDFTQE EWTLLDQAQR DLYRDVMLEN YKNLIILAGS ELFKRSLMSG
    61  LEQMEELRTG VTGVLQELDL QLKTKGSPLL QDISAERSPN GVQLERSNTA EKLYDSNHSG
   121  KVFNEHPFLM THMITHIGEK TSEDNQSGKA LRKNFPHSFY KKSHAEGKMP KCVKHEKAFN
   181  QFPNLTRQNK THTQEKLCEC KDCWRTFLNQ SSLKLHIRSH NGDKHYVCKE CGKAFSNSSH
   241  LIGHGRIHSG EKPYVCKECG KAFTQSTGLK LHIRTHSGEK PYKCKECGKA FTHSSYLTDH
   301  TRIHSGKKPY VCMECGKAFT RSTGLILHMR IHTGEKPYEC KECGKAFIHS SYLTKHVRIH
   361  SGEKLYLCKA CGKAFTRSSG LVLHMRTHTG EKPYECKECG KAFNNSSMLS QHVRIHTGEK
   421  PYECKECGKA FTQSSGLSTH LRTHTGEKAC ECKECGKAFA RSTNLNMHMR THTGEKPYAC
   481  KECGKAFRYS TYLNVHTRTH TGAKPYECKK CGKNFTQSSA LAKHLRTKAC EKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF846 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

seminal vesicle: 18 nTPM
urinary bladder: 14 nTPM
testis: 13 nTPM
ovary: 11 nTPM
prostate: 11 nTPM
endometrium: 10 nTPM

Single-cell type

late primary spermatocytes: 492 nCPM
early spermatids: 202 nCPM
microglia: 165 nCPM
podocytes: 149 nCPM
sertoli cells: 142 nCPM
papillary tip epithelial cells: 119 nCPM

Immune cell

myeloid DC: 6.9 nTPM
naive B-cell: 5.3 nTPM
plasmacytoid DC: 4.4 nTPM
memory CD8 T-cell: 4.2 nTPM
memory B-cell: 4.1 nTPM
naive CD8 T-cell: 3.9 nTPM

Brain region

midbrain: 32 nTPM
white matter: 31 nTPM
medulla oblongata: 30 nTPM
spinal cord: 30 nTPM
amygdala: 29 nTPM
thalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -0.81
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF846 as an antibody target. Whether an autoantibody or antibody against ZNF846 could matter depends on whether native ZNF846 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF846 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF846 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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