Seroatlas · Human Serome Atlas

ZNF836

Zinc finger protein 836

Also known as: FLJ16287, ZN836_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNA1
Gene: ZNF836
Ensembl: ENSG00000196267
Chromosome: 19
Canonical length: 936 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

936 residues, UniProt reviewed canonical sequence.

>Q6ZNA1|ZNF836
     1  MALTQGPLTF RDVAIEFSQE EWKSLDPVQK ALYWDVMLEN YRNLVFLGIL PKCMTKELPP
    61  IGNSNTGEKC QTVTLERHEC YDVENFYLRE IQKNLQDLEF QWKDGEINYK EVPMTYKNNL
   121  NGKRGQHSQE DVENKCIENQ LTLSFQSRLT ELQKFQTEGK IYECNQSEKT VNNSSLVSPL
   181  QRILPSVQTN ISKKYENEFL QLSLPTQLEK THIREKPYMC KGCGKAFRVS SSLINHQMVH
   241  TTEKPYKCNE CGKAFHRGSL LTIHQIVHTR GKPYQCGVCG KIFRQNSDLV NHRRSHTGEK
   301  PYKCNECGKS FSQSYNLAIH QRIHTGEKPY KCNECGKTFK QGSCLTTHQI IHTGEKPYQC
   361  DICGKVFRQN SNLVNHQRIH TGEKPYKCNI CGKSFSQSSN LATHQTVHSG NKPYKCDECG
   421  KTFKRSSSLT THQIIHTGEK PYTCDVCDKV FSQRSQLARH QRSHTGEKPY KCNECGKVFS
   481  QTSHLVGHRR IHTGEKPYKC DKCGKAFKQG SLLTRHKIIH TREKRYQCGE CGKVFSENSC
   541  LVRHLRIHTG EQPYKCNVCG KVFNYSGNLS IHKRIHTGEK PFQCNECGTV FRNYSCLARH
   601  LRIHTGQKPY KCNVCGKVFN DSGNLSNHKR IHTGEKPFQC NECGKVFSYY SCLARHRKIH
   661  TGEKPYKCND CGKAYTQRSS LTKHLIIHTG EKPYNCNEFG GAFIQSSKLA RYHRNPTGEK
   721  PHKCSHCGRT FSHITGLTYH QRRHTGEMPY KCIECGQVFN STSNLARHRR IHTGEKPYKC
   781  NECGKVFRHQ STLARHRSIH TGEKPYVCNE CGKAFRVRSI LVNHQKMHTG DKPYKCNECG
   841  KAFIERSKLV YHQRNHTGEK PYKCIECGKA FGRFSCLNKH QMIHSGEKPY KCNECGKSFI
   901  SRSGLTKHQT KHTAESLKTK FNVEKPLDVL LTSGFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF836 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 26 nTPM
pituitary gland: 9.1 nTPM
parathyroid gland: 8.4 nTPM
choroid plexus: 6.9 nTPM
thymus: 6.3 nTPM
blood vessel: 6.1 nTPM

Single-cell type

renal collecting duct principal cells: 16 nCPM
renal connecting tubule cells: 11 nCPM
papillary tip epithelial cells: 8.8 nCPM
esophageal apical cells: 7.9 nCPM
proximal tubule cells: 7.1 nCPM
renal collecting duct intercalated cells: 7.1 nCPM

Immune cell

basophil: 11 nTPM
NK-cell: 5.8 nTPM
memory CD8 T-cell: 4.5 nTPM
naive B-cell: 4.5 nTPM
memory CD4 T-cell: 4.1 nTPM
T-reg: 3.9 nTPM

Brain region

cerebellum: 16 nTPM
hypothalamus: 11 nTPM
cerebral cortex: 11 nTPM
white matter: 11 nTPM
pons: 10 nTPM
choroid plexus: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF836 as an antibody target. Whether an autoantibody or antibody against ZNF836 could matter depends on whether native ZNF836 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF836 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF836 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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