Seroatlas · Human Serome Atlas

ZNF780B

Zinc finger protein 780B

Also known as: Z780B_HUMAN, ZNF779

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6R6
Gene: ZNF780B
Ensembl: ENSG00000128000
Chromosome: 19
Canonical length: 833 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

833 residues, UniProt reviewed canonical sequence.

>Q9Y6R6|ZNF780B
     1  MVHGSVTFRD VAIDFSQEEW ECLQPDQRTL YRDVMLENYS HLISLGSSIS KPDVITLLEQ
    61  EKEPWIVVSK ETSRWYPDLE SKYGPEKISP ENDIFEINLP KHVIKQISKT LGLEAFYFRN
   121  DSEYRSRFEG RQGHQEGYIN QKIISYEEMP AYTHASPIHN THKPYECKEC GKYFSCGSNL
   181  IQHQSIHTGE KPYKCKECGK AFQLHIQLTR HQKFHTGEKT FECKECGKAF NLPTQLNRHK
   241  NIHTVKKLFE CKECGKSFNR SSNLTQHQSI HAGVKPYQCK ECGKAFNRGS NLIQHQKIHS
   301  NEKPFVCREC EMAFRYHYQL IEHCRIHTGE KPFECKECRK AFTLLTKLVR HQKIHMGEKP
   361  FECRECGKAF SLLNQLNRHK NIHTGEKPFE CKECGKSFNR SSNLIQHQSI HADVKPYECK
   421  ECGKGFNRGA NLIQHQKIHS NEKPFVCREC EMAFRYHYQL IQHCQIHTGG KPFECKECGK
   481  AFSLLTQLAR HKNIHTGEKP FECKDCGKAF NRGSNLVQHQ SIHTGEKPYE CKECGKAFRL
   541  HLQLSQHEKT HTGEKPFECK ECGKFFRRGS NLNQHRSIHT GKKPFECKEC GKAFRLHMHL
   601  IRHQKFHTGE KPFECKECGK AFSLHTQLNH HKNIHTGEKP FKCKECGKSF NRVSNLVQHQ
   661  SIHAGVKPYE CKECGKGFSR VSNLIQHQKT HSSAKPFVCK ECRKTFRYHY QLTEHYRIHT
   721  GEKPFECKEC GKAFGLLTQL AQHQIIHTGE KPFKCKECGK AFNRGSNLVQ PQSIHTGEKP
   781  YECKECGKAF RLHLQLSLHQ KLVQVRNPLN VRNVGQPSDI SSNLLNIRKF ILG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF780B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

retina: 13 nTPM
pituitary gland: 11 nTPM
cerebellum: 9.8 nTPM
ovary: 8.9 nTPM
thyroid gland: 8.1 nTPM
heart muscle: 7.7 nTPM

Single-cell type

distal convoluted tubule cells: 138 nCPM
choroid plexus epithelial cells: 122 nCPM
renal connecting tubule cells: 120 nCPM
proximal tubule cells: 117 nCPM
microglia: 110 nCPM
podocytes: 95 nCPM

Immune cell

plasmacytoid DC: 2.5 nTPM
naive CD4 T-cell: 2 nTPM
naive CD8 T-cell: 1.7 nTPM
naive B-cell: 1.6 nTPM
classical monocyte: 1.3 nTPM
memory CD4 T-cell: 1.3 nTPM

Brain region

cerebellum: 20 nTPM
choroid plexus: 16 nTPM
white matter: 15 nTPM
cerebral cortex: 14 nTPM
basal ganglia: 14 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.41
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF780B as an antibody target. Whether an autoantibody or antibody against ZNF780B could matter depends on whether native ZNF780B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF780B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF780B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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