Seroatlas · Human Serome Atlas

ZNF77

Zinc finger protein 77

Also known as: pT1, ZNF77_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15935
Gene
ZNF77
Ensembl
ENSG00000175691
Chromosome
19
Canonical length
545 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>Q15935|ZNF77
     1  MDCVIFEEVA VNFTPEEWAL LDHAQRSLYR DVMLETCRNL ASLDCYIYVR TSGSSSQRDV
    61  FGNGISNDEE IVKFTGSDSW SIFGENWRFD NTGDQHQIPQ RHLRSQLGRL CESNEGHQCG
   121  ETLSQTANLL VHKSYPTEAK PSECTKCGKA FENRQRSHTG QRPCKECGQA CSCLSCQSPP
   181  MKTQTVEKPC NCQDSRTASV TYVKSLSSKK SYECQKCGKA FICPSSFRGH VNSHHGQKTH
   241  ACKVCGKTFM YYSYLTRHVR THTGEKPYEC KECGKAFSCP SYFREHVRTH TGEKPYECKH
   301  CGKSFSCYSS FRDHVRTHTG EKPCQCKHCG KAFTCYSSLR EHGRTHSGEK PYECKECGKA
   361  FRYPSSLRAH MRMHTGEKPY VCKQCGKAFG CPTYFRRHVK THSGVKPYQC KECGKAYSFS
   421  SSLRIHVRTH TGEKPFECKH CGKAFSCHSS LREHVRTHSG EKPYECNQCG KAFSHAQYFQ
   481  KHVRSHSGVK PYECTECGKA YSCSSSLRVH VRTHTGERPY ECKQCGKTFR YLASLQAHVR
   541  THAGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF77 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
5.1 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 5.1 nTPM
  • breast: 4.3 nTPM
  • tongue: 3.8 nTPM
  • retina: 3.7 nTPM
  • ovary: 3.5 nTPM
  • testis: 3.4 nTPM

Single-cell type

  • syncytiotrophoblasts: 21 nCPM
  • myosatellite cells: 18 nCPM
  • differentiating spermatogonia: 17 nCPM
  • mucous neck cells: 17 nCPM
  • early primary spermatocytes: 16 nCPM
  • cytotrophoblasts: 11 nCPM

Immune cell

  • memory B-cell: 3.7 nTPM
  • MAIT T-cell: 3.5 nTPM
  • naive B-cell: 3.5 nTPM
  • naive CD8 T-cell: 3.4 nTPM
  • memory CD8 T-cell: 3.2 nTPM
  • memory CD4 T-cell: 3.1 nTPM

Brain region

  • cerebellum: 8.3 nTPM
  • white matter: 4.2 nTPM
  • cerebral cortex: 3.9 nTPM
  • amygdala: 3.5 nTPM
  • midbrain: 3.5 nTPM
  • pons: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0
gnomAD missense Z
-0.34
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF77 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF77 as an antibody target. Whether an autoantibody or antibody against ZNF77 could matter depends on whether native ZNF77 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF77 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF77 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF77. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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