ZNF75A
Zinc finger protein 75A
Also known as: FLJ31529, ZN75A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96N20
- Gene
- ZNF75A
- Ensembl
- ENSG00000162086
- Chromosome
- 16
- Canonical length
- 296 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli fibrillar center
OverviewNCBI Gene
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
296 residues, UniProt reviewed canonical sequence.
>Q96N20|ZNF75A
1 MYFSQEEWEL LDPTQKALYN DVMQENYETV ISLALFVLPK PKVISCLEQG EEPWVQVSPE
61 FKDSAGKSPT GLKLKNDTEN HQPVSLSDLE IQASAGVISK KAKVKVPQKT AGKENHFDMH
121 RVGKWHQDFP VKKRKKLSTW KQELLKLMDR HKKDCAREKP FKCQECGKTF RVSSDLIKHQ
181 RIHTEEKPYK CQQCDKRFRW SSDLNKHLTT HQGIKPYKCS WCGKSFSQNT NLHTHQRTHT
241 GEKPFTCHEC GKKFSQNSHL IKHRRTHTGE QPYTCSICRR NFSRRSSLLR HQKLHLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF75A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 16 nTPM
- retina: 16 nTPM
- parathyroid gland: 15 nTPM
- choroid plexus: 13 nTPM
- lymph node: 13 nTPM
- thymus: 12 nTPM
Single-cell type
- early primary spermatocytes: 118 nCPM
- choroid plexus epithelial cells: 74 nCPM
- myonuclei: 67 nCPM
- differentiating spermatogonia: 64 nCPM
- sertoli cells: 60 nCPM
- tuft cells: 58 nCPM
Immune cell
- naive B-cell: 44 nTPM
- naive CD4 T-cell: 39 nTPM
- NK-cell: 34 nTPM
- memory B-cell: 34 nTPM
- basophil: 30 nTPM
- eosinophil: 29 nTPM
Brain region
- cerebellum: 16 nTPM
- cerebral cortex: 14 nTPM
- white matter: 14 nTPM
- choroid plexus: 13 nTPM
- hypothalamus: 11 nTPM
- thalamus: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.01
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF75A as an antibody target. Whether an autoantibody or antibody against ZNF75A could matter depends on whether native ZNF75A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF75A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF75A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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