Seroatlas · Human Serome Atlas

ZNF747

Zinc finger protein 747

Also known as: MGC2474, ZN747_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BV97
Gene: ZNF747
Ensembl: ENSG00000169955
Chromosome: 16
Canonical length: 330 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q9BV97|ZNF747
     1  MTDPSLGLTV PMAPPLAPLP PRDPNGAGSE WRKPGAVSFA DVAVYFSREE WGCLRPAQRA
    61  LYRDVMRETY GHLGALGVGG SKPALISWVE EKAELWDPAA QDPEVAKCPT EADPDSRNKE
   121  EERQREGTGA LEKPDPVAAG SPGLKAPQAP FAGLEQLSKA RRRSRPRFFA HPPVPRADQR
   181  HGCYVCGKSF AWRSTLVEHI YSHRGEKPFH CADCGKGFGH ASSLSKHRAI HRGERPHRCP
   241  ECGRAFMRRT ALTSHLRVHT GEKPYRCPQC GRCFGLKTGM AKHQWVHRPG GEGRRGRRPG
   301  GLSVTLTPVR GDLDPPVGFQ LYPEIFQECG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF747 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 7.6 nTPM
liver: 7.2 nTPM
skeletal muscle: 6.1 nTPM
seminal vesicle: 6 nTPM
tongue: 6 nTPM
heart muscle: 5.9 nTPM

Single-cell type

cardiomyocytes: 26 nCPM
epicardial cells: 4.5 nCPM
ependymal cells: 3.9 nCPM
oligodendrocytes: 3.3 nCPM
brain excitatory neurons: 2.8 nCPM
brain inhibitory neurons: 2.8 nCPM

Immune cell

basophil: 8 nTPM
naive B-cell: 5.3 nTPM
plasmacytoid DC: 5.3 nTPM
naive CD4 T-cell: 5.2 nTPM
memory B-cell: 4.7 nTPM
NK-cell: 4.5 nTPM

Brain region

white matter: 17 nTPM
cerebellum: 16 nTPM
medulla oblongata: 16 nTPM
pons: 16 nTPM
thalamus: 16 nTPM
basal ganglia: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.07
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF747 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF747 as an antibody target. Whether an autoantibody or antibody against ZNF747 could matter depends on whether native ZNF747 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF747 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF747 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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