Seroatlas · Human Serome Atlas

ZNF738

Zinc finger protein 738

Also known as: ZN738_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NE65
Gene: ZNF738
Ensembl: ENSG00000172687
Chromosome: 19
Canonical length: 375 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q8NE65|ZNF738
     1  MDDLRYGVYP VKGASGYPGA ERNLLEYSYF EKGPLTFRDV VIEFSQEEWQ CLDTAQQDLY
    61  RKVMLENFRN LVFLGIDVSK PDLITCLEQG KDPWNMKRHS MVATPPVTYS HFAQDLWPQP
   121  GIKDSFQKVI LREYGNYGHK DLQLRKGCKS VNECNVQKEG YNELKEYLTT TQSKIFQCDK
   181  YVKVFHKFLN SNTHKTRHTG KKPFKCKKCG KSFCMLLHLG QHKIIHIREN SYQCEECGKA
   241  FKWFSTLTRH KRIHTGDKSY KHEECGKGFN HSTTLTRHKV IHAGEKHYKC EKCGKDFKQS
   301  SHLTKHKTIH AGEKPYKCEG CGKAFCQFSY LTKHKIIHTG EKPYKCEECG KAFNWYSHLT
   361  RHKIIHTGEK PYKCE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF738 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 13 nTPM
cerebellum: 11 nTPM
ovary: 9.9 nTPM
spinal cord: 8.3 nTPM
lymph node: 7.9 nTPM
thymus: 7.7 nTPM

Single-cell type

migrating cytotrophoblasts: 41 nCPM
sertoli cells: 41 nCPM
extravillous trophoblasts: 38 nCPM
tuft cells: 35 nCPM
cytotrophoblasts: 33 nCPM
neutrophils: 33 nCPM

Immune cell

basophil: 5.6 nTPM
neutrophil: 5.1 nTPM
non-classical monocyte: 4.8 nTPM
eosinophil: 4.6 nTPM
NK-cell: 4.6 nTPM
naive B-cell: 4.4 nTPM

Brain region

white matter: 21 nTPM
cerebellum: 17 nTPM
basal ganglia: 16 nTPM
medulla oblongata: 15 nTPM
pons: 15 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0.04
gnomAD missense Z: 0.42

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF738 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF738 as an antibody target. Whether an autoantibody or antibody against ZNF738 could matter depends on whether native ZNF738 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF738 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF738 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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