Seroatlas · Human Serome Atlas

ZNF737

Zinc finger protein 737

Also known as: ZN737_HUMAN, ZNF102

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75373
Gene: ZNF737
Ensembl: ENSG00000237440
Chromosome: 19
Canonical length: 536 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>O75373|ZNF737
     1  MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYRNL VFLGIVVSKP DLITCLEQGK
    61  KPLTMKKHEM VANPSVTCSH FARDLWPEQS IKDSFQKVTL RRYENYGHDN LQFKKGCESV
   121  DECKVHKRGY NGLNQYLTTT QSKIFQCDKY VKVIHKFSNS NRHKIRHTGK KPFKCIECGK
   181  AFNQSSTLTT HKKIHTGEKP FKCEECGKAF NWSSHLTTHK RIHTGEKRYK CEDCGKAFSR
   241  FSYLTAHKII HSGEKPYKCE ECGKAFKRSS NLTTHKIIHT GEKPYKCEEC GKAFKRSSIL
   301  TAHKIIHSGE KPYKCEECGK AFKHPSVLTT HKRIHTGEKP YKCEECGRAF KYFSSLTTHK
   361  IIHSGEKPYK CEECGKAFNW SSHLTTHKRI HTGEKPYKCE ECGEAFKYSS SLTTHKIIHT
   421  GQQPFKCEEC GKAFKCFSIL TTHKRIHTGE KPYKCEECGK AFNSSSHLTA HKRIHTGEKP
   481  YKCERCGKAF KRSFILTRHK RIHTGEKPYK CEECGKGFKC PSTLTTHKVI HTGEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF737 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 36 nTPM
ovary: 27 nTPM
thymus: 19 nTPM
lymph node: 16 nTPM
tonsil: 14 nTPM
breast: 13 nTPM

Single-cell type

corticotrophs: 61 nCPM
brain inhibitory neurons: 42 nCPM
granulosa cells: 41 nCPM
papillary tip epithelial cells: 38 nCPM
thyrotrophs: 36 nCPM
podocytes: 34 nCPM

Immune cell

naive B-cell: 9.1 nTPM
memory B-cell: 7.9 nTPM
memory CD8 T-cell: 6.7 nTPM
naive CD4 T-cell: 6.4 nTPM
memory CD4 T-cell: 5.9 nTPM
T-reg: 5.3 nTPM

Brain region

basal ganglia: 65 nTPM
white matter: 55 nTPM
cerebellum: 55 nTPM
hypothalamus: 50 nTPM
cerebral cortex: 48 nTPM
hippocampal formation: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: -1.43
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF737 as an antibody target. Whether an autoantibody or antibody against ZNF737 could matter depends on whether native ZNF737 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF737 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF737 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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