Seroatlas · Human Serome Atlas

ZNF674

Zinc finger protein 674

Also known as: MRX92, ZN674_HUMAN, ZNF673B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M3X9
Gene: ZNF674
Ensembl: ENSG00000251192
Chromosome: X
Canonical length: 581 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked cognitive disabilities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q2M3X9|ZNF674
     1  MAMSQESLTF KDVFVDFTLE EWQQLDSAQK NLYRDVMLEN YSHLVSVGHL VGKPDVIFRL
    61  GPGDESWMAD GGTPVRTCAG EDRPEVWEVD EQIDHYKESQ DKFLWQAAFI GKETLKDESG
   121  QECKICRKII YLNTDFVSVK QRLPKYYSWE RCSKHHLNFL GQNRSYVRKK DDGCKAYWKV
   181  CLHYNLHKAQ PAERFFDPNQ RGKALHQKQA LRKSQRSQTG EKLYKCTECG KVFIQKANLV
   241  VHQRTHTGEK PYECCECAKA FSQKSTLIAH QRTHTGEKPY ECSECGKTFI QKSTLIKHQR
   301  THTGEKPFVC DKCPKAFKSS YHLIRHEKTH IRQAFYKGIK CTTSSLIYQR IHTSEKPQCS
   361  EHGKASDEKP SPTKHWRTHT KENIYECSKC GKSFRGKSHL SVHQRIHTGE KPYECSICGK
   421  TFSGKSHLSV HHRTHTGEKP YECRRCGKAF GEKSTLIVHQ RMHTGEKPYK CNECGKAFSE
   481  KSPLIKHQRI HTGERPYECT DCKKAFSRKS TLIKHQRIHT GEKPYKCSEC GKAFSVKSTL
   541  IVHHRTHTGE KPYECRDCGK AFSGKSTLIK HQRSHTGDKN L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF674 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

retina: 3.6 nTPM
liver: 2 nTPM
pancreas: 1.9 nTPM
prostate: 1.8 nTPM
choroid plexus: 1.7 nTPM
ovary: 1.6 nTPM

Single-cell type

cardiomyocytes: 58 nCPM
neutrophils: 28 nCPM
medullary thymic epithelial cells: 24 nCPM
myonuclei: 22 nCPM
bergmann glia: 21 nCPM
renal collecting duct intercalated cells: 21 nCPM

Immune cell

neutrophil: 1.7 nTPM
intermediate monocyte: 1.1 nTPM
eosinophil: 1 nTPM
basophil: 0.9 nTPM
classical monocyte: 0.7 nTPM
memory B-cell: 0.7 nTPM

Brain region

cerebellum: 9.7 nTPM
white matter: 8.6 nTPM
cerebral cortex: 8.1 nTPM
pons: 7.9 nTPM
basal ganglia: 7.7 nTPM
hypothalamus: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF674 as an antibody target. Whether an autoantibody or antibody against ZNF674 could matter depends on whether native ZNF674 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF674 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF674 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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