Seroatlas · Human Serome Atlas

ZNF649

Zinc finger protein 649

Also known as: FLJ12644, ZN649_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BS31
Gene: ZNF649
Ensembl: ENSG00000198093
Chromosome: 19
Canonical length: 505 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of osteoblast differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q9BS31|ZNF649
     1  MTKAQESLTL EDVAVDFTWE EWQFLSPAQK DLYRDVMLEN YSNLVSVGYQ AGKPDALTKL
    61  EQGEPLWTLE DEIHSPAHPE IEKADDHLQQ PLQNQKILKR TGQRYEHGRT LKSYLGLTNQ
   121  SRRYNRKEPA EFNGDGAFLH DNHEQMPTEI EFPESRKPIS TKSQFLKHQQ THNIEKAHEC
   181  TDCGKAFLKK SQLTEHKRIH TGKKPHVCSL CGKAFYKKYR LTEHERAHRG EKPHGCSLCG
   241  KAFYKRYRLT EHERAHKGEK PYGCSECGKA FPRKSELTEH QRIHTGIKPH QCSECGRAFS
   301  RKSLLVVHQR THTGEKPHTC SECGKGFIQK GNLNIHQRTH TGEKPYGCID CGKAFSQKSC
   361  LVAHQRYHTG KTPFVCPECG QPCSQKSGLI RHQKIHSGEK PYKCSDCGKA FLTKTMLIVH
   421  HRTHTGERPY GCDECEKAYF YMSCLVKHKR IHSREKRGDS VKVENPSTAS HSLSPSEHVQ
   481  GKSPVNMVTV AMVAGQCEFA HILHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF649 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

prostate: 20 nTPM
retina: 12 nTPM
breast: 9.4 nTPM
ovary: 9 nTPM
parathyroid gland: 8.9 nTPM
placenta: 8.3 nTPM

Single-cell type

prostatic glandular cells: 20 nCPM
lactotrophs: 16 nCPM
oligodendrocytes: 14 nCPM
corticotrophs: 13 nCPM
oligodendrocyte progenitor cells: 12 nCPM
tuft cells: 12 nCPM

Immune cell

MAIT T-cell: 12 nTPM
T-reg: 10 nTPM
naive B-cell: 9.1 nTPM
eosinophil: 7.7 nTPM
NK-cell: 7.7 nTPM
naive CD4 T-cell: 7.4 nTPM

Brain region

white matter: 50 nTPM
hypothalamus: 42 nTPM
cerebellum: 42 nTPM
medulla oblongata: 40 nTPM
cerebral cortex: 38 nTPM
thalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.07
gnomAD missense Z: 1.41
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF649 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF649 as an antibody target. Whether an autoantibody or antibody against ZNF649 could matter depends on whether native ZNF649 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF649 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF649 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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