Seroatlas · Human Serome Atlas

ZNF628

Zinc finger protein 628

Also known as: ZEC, Zfp628, ZN628_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5EBL2
Gene: ZNF628
Ensembl: ENSG00000197483
Chromosome: 19
Canonical length: 1059 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1059 residues, UniProt reviewed canonical sequence.

>Q5EBL2|ZNF628
     1  MSGVMVGSHA DMAPASTAEG AGEKPGPAAP APAAQYECGE CGKSFRWSSR LLHHQRTHTG
    61  ERPYKCPDCP KAFKGSSALL YHQRGHTGER PYQCPDCPKA FKRSSLLQIH RSVHTGLRAF
   121  ICGQCGLAFK WSSHYQYHLR QHTGERPYPC PDCPKAFKNS SSLRRHRHVH TGERPYTCGV
   181  CGKSFTQSTN LRQHQRVHTG ERPFRCPLCP KTFTHSSNLL LHQRTHGAAP APGTASAAPP
   241  PQSREPGKVF VCDAYLQRHL QPHSPPAPPA PPPPPPPVVP ELFLAAAETT VELVYRCDGC
   301  EQGFSSEELL LEHQPCPGPD AAPQPQEAPA EAPKADQPPS PLPQPPPPAA APAPGFACLP
   361  CGKSFRTVAG LSRHQHSHGA AGGQAFRCGS CDGSFPQLAS LLAHQQCHVE EAAAGRPPPQ
   421  AEAAEVTCPQ EPLAPAAPVP PPPPSAPASA ERPYKCAECG KSFKGSSGLR YHLRDHTGER
   481  PYQCGECGKA FKRSSLLAIH QRVHTGLRAF TCGQCGLTFK WSSHYQYHLR LHSGERPYAC
   541  GECGKAFRNT SCLRRHRHVH TGERPHACGV CGKSFAQTSN LRQHQRVHTG ERPFRCPLCP
   601  KTFTHSSNLL LHQRTHSAER PFTCPICGRG FVMAAYLQRH LRTHAPANTP PSTTAPAAGP
   661  QPPAPLAAAR APPATQDVHV LPHLQATLSL EVAGGTAQAP SLGPAAPNSQ TFLLVQTAQG
   721  LQLIPSSVQP PTPPPPPAPP KLILLPSSSA GAGGGRARQG PRAVGKAGQG AGVVWLPGPG
   781  GLGVQGAASA GASGTGQSLI VLQNVGGGEA GPQEMSGVQL QPLRPAPEVT TVQLQPAQEV
   841  TTVQLQPAQE VTTVQLQPAQ EVTTVQLQPV AGQLSNSSGG AVATEAPNLL VVQSGAAEEL
   901  LTGPGPGEAG DGEASTGVVQ DVLFETLQTD EGLQSVLVLS GADGEQTRLC VQEVETLPPG
   961  LTEPPATGPP GQKLLIIRSA PATELLDSSN TGGGTATLQL LAPPPSGPAS GPAGLPGAPA
  1021  SQMVQVVPAG AGPGVMTPQG LPSIQIVQTL PAVQLVHTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF628 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
skeletal muscle: 13 nTPM
skin: 7.8 nTPM
endometrium: 6.1 nTPM
colon: 5.9 nTPM
blood vessel: 5.2 nTPM

Single-cell type

late spermatids: 213 nCPM
early spermatids: 38 nCPM
late primary spermatocytes: 27 nCPM
megakaryocyte-erythroid progenitors: 20 nCPM
erythrocyte progenitors: 13 nCPM
paneth cells: 12 nCPM

Immune cell

non-classical monocyte: 0.4 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

cerebral cortex: 12 nTPM
amygdala: 11 nTPM
white matter: 10 nTPM
basal ganglia: 10 nTPM
hippocampal formation: 9.8 nTPM
thalamus: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.91
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF628 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TAF4B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF628 as an antibody target. Whether an autoantibody or antibody against ZNF628 could matter depends on whether native ZNF628 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF628 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF628 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...