Seroatlas · Human Serome Atlas

TAF4B

Transcription initiation factor TFIID subunit 4B

Also known as: TAF2C2, TAF4B_HUMAN, TAFII105

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92750
Gene: TAF4B
Ensembl: ENSG00000141384
Chromosome: 18
Canonical length: 862 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center
Quaternary structure: Homodimer

OverviewNCBI Gene

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

862 residues, UniProt reviewed canonical sequence.

>Q92750|TAF4B
     1  MPAGLTEPAG AAPPAAVSAS GTVTMAPAGA LPVRVESTPV ALGAVTKAPV SVCVEPTASQ
    61  PLRSPVGTLV TKVAPVSAPP KVSSGPRLPA PQIVAVKAPN TTTIQFPANL QLPPGTVLIK
   121  SNSGPLMLVS PQQTVTRAET TSNITSRPAV PANPQTVKIC TVPNSSSQLI KKVAVTPVKK
   181  LAQIGTTVVT TVPKPSSVQS VAVPTSVVTV TPGKPLNTVT TLKPSSLGAS STPSNEPNLK
   241  AENSAAVQIN LSPTMLENVK KCKNFLAMLI KLACSGSQSP EMGQNVKKLV EQLLDAKIEA
   301  EEFTRKLYVE LKSSPQPHLV PFLKKSVVAL RQLLPNSQSF IQQCVQQTSS DMVIATCTTT
   361  VTTSPVVTTT VSSSQSEKSI IVSGATAPRT VSVQTLNPLA GPVGAKAGVV TLHSVGPTAA
   421  TGGTTAGTGL LQTSKPLVTS VANTVTTVSL QPEKPVVSGT AVTLSLPAVT FGETSGAAIC
   481  LPSVKPVVSS AGTTSDKPVI GTPVQIKLAQ PGPVLSQPAG IPQAVQVKQL VVQQPSGGNE
   541  KQVTTISHSS TLTIQKCGQK TMPVNTIIPT SQFPPASILK QITLPGNKIL SLQASPTQKN
   601  RIKENVTSCF RDEDDINDVT SMAGVNLNEE NACILATNSE LVGTLIQSCK DEPFLFIGAL
   661  QKRILDIGKK HDITELNSDA VNLISQATQE RLRGLLEKLT AIAQHRMTTY KASENYILCS
   721  DTRSQLKFLE KLDQLEKQRK DLEEREMLLK AAKSRSNKED PEQLRLKQKA KELQQLELAQ
   781  IQHRDANLTA LAAIGPRKKR PLESGIEGLK DNLLASGTSS LTATKQLHRP RITRICLRDL
   841  IFCMEQEREM KYSRALYLAL LK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 4.3 nTPM

Expression across tissuesHPA

Tissue

testis: 4.3 nTPM
tonsil: 3 nTPM
lymph node: 2.9 nTPM
bone marrow: 2.7 nTPM
appendix: 2.6 nTPM
ovary: 2.6 nTPM

Single-cell type

endometrial luminal cells: 440 nCPM
endometrial glandular cells: 267 nCPM
endometrial ciliated cells: 244 nCPM
choroid plexus epithelial cells: 216 nCPM
erythrocyte progenitors: 205 nCPM
basal keratinocytes: 198 nCPM

Immune cell

memory B-cell: 2.3 nTPM
naive B-cell: 2 nTPM
naive CD4 T-cell: 2 nTPM
naive CD8 T-cell: 1.6 nTPM
MAIT T-cell: 1 nTPM
memory CD8 T-cell: 1 nTPM

Brain region

cerebral cortex: 10 nTPM
pons: 8.6 nTPM
white matter: 7.7 nTPM
basal ganglia: 6.6 nTPM
cerebellum: 6.1 nTPM
medulla oblongata: 6.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAF4B.

Disease | AllUniProt

Conditions TAF4B is implicated in, by any mechanism.

Spermatogenic failure 13 (SPGF13) MIM:615841

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 182 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 13

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.23
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF4B as an antibody target. Whether an autoantibody or antibody against TAF4B could matter depends on whether native TAF4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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