Seroatlas · Human Serome Atlas

ZNF614

Zinc finger protein 614

Also known as: FLJ21941, ZN614_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N883
Gene: ZNF614
Ensembl: ENSG00000142556
Chromosome: 19
Canonical length: 585 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q8N883|ZNF614
     1  MIKTQESLTL EDVAVEFSWE EWQLLDTAQK NLYRDVMVEN YNHLVSLGYQ TSKPDVLSKL
    61  AHGQEPWTTD AKIQNKNCPG IGKVDSHLQE HSPNQRLLKS VQQCNGQNTL RNIVHLSKTH
   121  FPIVQNHDTF DLYRKNLKSS LSLINQKRRH GINNPVEFIG GEKTLLHGKH ERTHTKTRFS
   181  ENAKCIHTKF QVFKHQRTQK IEKPHACIEC EQTFLRKSQL IYHENICIQE NPGSGQCEKL
   241  SRSVLFTKHL KTNTTDKICI PNEYRKGSTV KSSLITHQQT HTEEKSYMCS ECGKGFTMKR
   301  YLIAHQRTHS GEKPYVCKEC GKGFTVKSNL IVHQRTHTGE KPYICSECGK GFTMKRYLVV
   361  HQRTHTGEKP YMCSECGKGF TVKSNLIVHQ RSHTGEKSYI CSECGKGFTV KRTLVIHQRT
   421  HTGEKSYICN ECGKGFTTKR TLIIHQRTHT GEKPYECNEC GKAFSQKICL IQHERCHTGK
   481  TPFVCTECGK SYSHKYGLIT HQRIHTGEKP YECNECGKAF TTKSVLNVHQ RTHTGERPYG
   541  CSDCEKAFSH LSNLVKHKKM HTREMGRISQ VENSCNGESQ LLPYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF614 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

retina: 9.4 nTPM
prostate: 8.7 nTPM
thyroid gland: 7.9 nTPM
ovary: 7.2 nTPM
placenta: 7.1 nTPM
testis: 7 nTPM

Single-cell type

early spermatids: 73 nCPM
late spermatids: 50 nCPM
cardiomyocytes: 38 nCPM
syncytiotrophoblasts: 19 nCPM
retinal horizontal cells: 16 nCPM
megakaryocyte-erythroid progenitors: 15 nCPM

Immune cell

NK-cell: 6.2 nTPM
naive CD4 T-cell: 4.8 nTPM
MAIT T-cell: 4.4 nTPM
gdT-cell: 3.8 nTPM
memory CD8 T-cell: 3.7 nTPM
T-reg: 3.7 nTPM

Brain region

cerebellum: 27 nTPM
white matter: 23 nTPM
hypothalamus: 21 nTPM
cerebral cortex: 19 nTPM
medulla oblongata: 19 nTPM
midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF614 as an antibody target. Whether an autoantibody or antibody against ZNF614 could matter depends on whether native ZNF614 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF614 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF614 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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