Seroatlas · Human Serome Atlas

ZNF608

Zinc finger protein 608

Also known as: DKFZp434M098, KIAA1281, NY-REN-36, ZN608_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULD9
Gene: ZNF608
Ensembl: ENSG00000168916
Chromosome: 5
Canonical length: 1512 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1512 residues, UniProt reviewed canonical sequence.

>Q9ULD9|ZNF608
     1  MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM NNSTTTTSSS
    61  NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE TSKSKVKRSK TSKDANKSLP
   121  SAALYGIPEI SSTGKRQEVQ GRPGEATGMN SALGQSVSSG GSGNPNSNST STSTSAATAG
   181  AGSCGKSKEE KPGKSQSSRG AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA
   241  KSNGGGASPF HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT
   301  EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV GVNTCEVGVV
   361  TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT YVGTLLDCTK HDWAPPRFCE
   421  SPTSDLEMRG GRGRGKRARS AAAAPGSEAS FTESRGLQNK NRGGANGKGR RGSLNASGRR
   481  TPPNCAAEDI KASPSSTNKR KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET
   541  TFLDQGCSSP VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE
   601  GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS IIGAKAGKNS
   661  GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL EAEGLIDKKN LGDKEKGKKA
   721  TNCKTDKNLS KLKSARPIAP APAPTPPQLI AIPTATFTTT TTGTIPGLPS LTTTVVQATP
   781  KSPPLKPIQP KPTIMGEPIT VNPALVSLKD KKKKEKRKLK DKEGKETGSP KMDAKLGKLE
   841  DSKGASKDLP GHFLKDHLNK NEGLANGLSE SQESRMASIK AEADKVYTFT DNAPSPSIGS
   901  ASRLECSTLV NGQAPMAPLH VLTQNGAESS AAKTSSPAYS DISDAADDGG SDSRSEGMRS
   961  KASSPSDIIS SKDSVVKGHS STTAQSSQLK ESHSPYYHSY DPYYSPSYMH PGQVGAPAAG
  1021  NSGSTQGMKI KKESEEDAEK KDKAEQLDSK KVDHNSASLQ PQHQSVITQR HPALAQSLYY
  1081  GQYAYGLYMD QKSLMATSPA YRQQYEKYYE DQRLAEQKMA QTGRGDCERK SELPLKELGK
  1141  EETKQKNMPS ATISKAPSTP EPNKNHSKLG PSVPNKTEET GKSQLLSNHQ QQLQADSFKA
  1201  KQMENHQLIK EAVEMKSVMD SMKQTGVDPT SRFKQDPDSR TWHHYVYQPK YLDQQKSEEL
  1261  DREKKLKEDS PRKTPNKESG VPSLPVSLTS IKEEPKEAKH PDSQSMEESK LKNDDRKTPV
  1321  NWKDSRGTRV AVSSPMSQHQ SYIQYLHAYP YPQMYDPSHP AYRAVSPVLM HSYPGAYLSP
  1381  GFHYPVYGKM SGREETEKVN TSPSVNTKTT TESKALDLLQ QHANQYRSKS PAPVEKATAE
  1441  REREAERERD RHSPFGQRHL HTHHHTHVGM GYPLIPGQYD PFQGLTSAAL VASQQVAAQA
  1501  SASGMFPGQR RE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF608 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

retina: 20 nTPM
duodenum: 9.6 nTPM
spinal cord: 9 nTPM
lung: 8.7 nTPM
adrenal gland: 8.2 nTPM
cerebellum: 8.2 nTPM

Single-cell type

neutrophils: 476 nCPM
pituitary stem cells: 364 nCPM
tuft cells: 357 nCPM
oligodendrocyte progenitor cells: 298 nCPM
oligodendrocytes: 295 nCPM
adrenal cortex cells: 242 nCPM

Immune cell

basophil: 2.5 nTPM
naive B-cell: 1.5 nTPM
memory B-cell: 0.5 nTPM
plasmacytoid DC: 0.4 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0 nTPM

Brain region

white matter: 42 nTPM
medulla oblongata: 38 nTPM
basal ganglia: 37 nTPM
midbrain: 35 nTPM
thalamus: 35 nTPM
cerebellum: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF608 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DYNLL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF608 as an antibody target. Whether an autoantibody or antibody against ZNF608 could matter depends on whether native ZNF608 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF608 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF608 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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