Seroatlas · Human Serome Atlas

ZNF607

Zinc finger protein 607

Also known as: FLJ14802, MGC13071, ZN607_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SK3
Gene: ZNF607
Ensembl: ENSG00000198182
Chromosome: 19
Canonical length: 696 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrial inner membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

696 residues, UniProt reviewed canonical sequence.

>Q96SK3|ZNF607
     1  MSYGSITFGD VAIDFSHQEW EYLSLVQKTL YQEVMMENYD NLVSLAGHSV SKPDLITLLE
    61  QGKEPWMIVR EETRGECTDL DSRCEIISDG KMQLYRKHSC VTLHQRIHNG QKPYECKQCQ
   121  KSFSHLTELM VHQTIHTSEE PDQCEKFRKA FSHLTDLRKH QKINAREKPY ECEECGKVFS
   181  YPANLAQHGK VHVEKPYECK ECGEAFRTSR QLTVHHRFHY GEKPYECKEC GKAFSVYGRL
   241  SRHQSIHTGE KPFECNKCGK SFRLKAGLKV HQSIHTGEKP HECKECGKAF RQFSHLVGHK
   301  RIHTGEKPYE CKECGKGFTC RYQLTMHQRI YSGEKHYECK ENGEAFSSGH QLTAPHTFES
   361  VEKPYKCEEC GKAFSVHGRL TRHQGIHSGK KPYECNKCGK SFRLNSSLKI HQNIHTGEKP
   421  YKCKECGKAF SQRAHLAHHN RIHTGYKPFE CKECGKSFRC ASYLVIHERI HTGEKPYVCQ
   481  ECGKGFSYSH KLTIHRRVHT GEKPYECKEC GKAFSVSGQL TQHLSIHSGK KPFECNKCGK
   541  SFRFISVLKA HQNIHSAEKP YECKECGKAF RHATSLIYHD RTHAGEKSYE CKECGETFSH
   601  ASHLIIHERI HTSDKPYECK RCGKAFHCAS YLVRHESVHA DGNPYMCEEC GKAFNSSHEL
   661  SIHHRVHTGE KPFKCNKCRR SFRLRSILEV HQRIHI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF607 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

testis: 8.7 nTPM
cerebellum: 5.6 nTPM
pituitary gland: 5.3 nTPM
parathyroid gland: 4.9 nTPM
ovary: 4.4 nTPM
retina: 4.4 nTPM

Single-cell type

late spermatids: 13 nCPM
tuft cells: 12 nCPM
early spermatids: 10 nCPM
cardiomyocytes: 2.9 nCPM
late primary spermatocytes: 2.8 nCPM
pdcs: 2.6 nCPM

Immune cell

memory B-cell: 3 nTPM
memory CD8 T-cell: 2.8 nTPM
NK-cell: 2.4 nTPM
naive CD8 T-cell: 2.3 nTPM
memory CD4 T-cell: 2.1 nTPM
naive B-cell: 2 nTPM

Brain region

medulla oblongata: 15 nTPM
white matter: 14 nTPM
cerebellum: 13 nTPM
basal ganglia: 12 nTPM
thalamus: 12 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: -0.21
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF607 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF607 as an antibody target. Whether an autoantibody or antibody against ZNF607 could matter depends on whether native ZNF607 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF607 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF607 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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