Seroatlas · Human Serome Atlas

ZNF57

Zinc finger protein 57

Also known as: ZNF424, ZNF57_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q68EA5
Gene
ZNF57
Ensembl
ENSG00000171970
Chromosome
19
Canonical length
555 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q68EA5|ZNF57
     1  MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFRNL ASVDDGTQFK ANGSVSLQDM
    61  YGQEKSKEQT IPNFTGNNSC AYTLEKNCEG YGTEDHHKNL RNHMVDRFCT HNEGNQYGEA
   121  IHQMPDLTLH KKVSAGEKPY ECTKCRTVFT HLSSLKRHVK SHCGRKAPPG EECKQACICP
   181  SHLHSHGRTD TEEKPYKCQA CGQTFQHPRY LSHHVKTHTA EKTYKCEQCR MAFNGFASFT
   241  RHVRTHTKDR PYKCQECGRA FIYPSTFQRH MTTHTGEKPY KCQHCGKAFT YPQAFQRHEK
   301  THTGEKPYEC KQCGKTFSWS ETLRVHMRIH TGDKLYKCEH CGKAFTSSRS FQGHLRTHTG
   361  EKPYECKQCG KAFTWSSTFR EHVRIHTQEQ LYKCEQCGKA FTSSRSFRGH LRTHTGEKPY
   421  ECKQCGKTFT WSSTFREHVR IHTQEQLHKC EHCGKAFTSS RAFQGHLRMH TGEKPYECKQ
   481  CGKTFTWSST LHNHVRMHTG EKPHKCKQCG MSFKWHSSFR NHLRMHTGQK SHECQSYSKA
   541  FSCQVILSKT SESTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF57 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • testis: 25 nTPM
  • skin: 17 nTPM
  • stomach: 11 nTPM
  • esophagus: 8.7 nTPM
  • rectum: 8.7 nTPM
  • colon: 7.7 nTPM

Single-cell type

  • oocytes: 138 nCPM
  • early spermatids: 88 nCPM
  • late spermatids: 83 nCPM
  • late primary spermatocytes: 51 nCPM
  • suprabasal keratinocytes: 35 nCPM
  • esophageal apical cells: 34 nCPM

Immune cell

  • naive CD4 T-cell: 5.5 nTPM
  • T-reg: 5.5 nTPM
  • NK-cell: 5.1 nTPM
  • memory CD4 T-cell: 4.8 nTPM
  • naive CD8 T-cell: 4.8 nTPM
  • memory CD8 T-cell: 4.5 nTPM

Brain region

  • cerebellum: 20 nTPM
  • cerebral cortex: 7.6 nTPM
  • pons: 6.8 nTPM
  • hippocampal formation: 6.7 nTPM
  • thalamus: 6.7 nTPM
  • white matter: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
-0.81
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF57 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF57 as an antibody target. Whether an autoantibody or antibody against ZNF57 could matter depends on whether native ZNF57 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF57 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF57 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF57. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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