Seroatlas · Human Serome Atlas

ZNF540

Zinc finger protein 540

Also known as: DKFZp547B0714, ZN540_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDQ6
Gene: ZNF540
Ensembl: ENSG00000171817
Chromosome: 19
Canonical length: 660 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Enables mRNA regulatory element binding translation repressor activity. Involved in negative regulation of DNA-templated transcription and negative regulation of translation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

660 residues, UniProt reviewed canonical sequence.

>Q8NDQ6|ZNF540
     1  MAHALVTFRD VAIDFSQKEW ECLDTTQRKL YRDVMLENYN NLVSLGYSGS KPDVITLLEQ
    61  GKEPCVVARD VTGRQCPGLL SRHKTKKLSS EKDIHEISLS KESIIEKSKT LRLKGSIFRN
   121  EWQNKSEFEG QQGLKERSIS QKKIVSKKMS TDRKRPSFTL NQRIHNSEKS CDSHLVQHGK
   181  IDSDVKHDCK ECGSTFNNVY QLTLHQKIHT GEKSCKCEKC GKVFSHSYQL TLHQRFHTGE
   241  KPYECQECGK TFTLYPQLNR HQKIHTGKKP YMCKKCDKGF FSRLELTQHK RIHTGKKSYE
   301  CKECGKVFQL IFYFKEHERI HTGKKPYECK ECGKAFSVCG QLTRHQKIHT GVKPYECKEC
   361  GKTFRLSFYL TEHRRTHAGK KPYECKECGK SFNVRGQLNR HKTIHTGIKP FACKVCEKAF
   421  SYSGDLRVHS RIHTGEKPYE CKECGKAFML RSVLTEHQRL HTGVKPYECK ECGKTFRVRS
   481  QISLHKKIHT DVKPYKCVRC GKTFRFGFYL TEHQRIHTGE KPYKCKECGK AFIRRGNLKE
   541  HLKIHSGLKP YDCKECGKSF SRRGQFTEHQ KIHTGVKPYK CKECGKAFSR SVDLRIHQRI
   601  HTGEKPYECK QCGKAFRLNS HLTEHQRIHT GEKPYECKVC RKAFRQYSHL YQHQKTHNVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF540 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

retina: 24 nTPM
cerebellum: 19 nTPM
pituitary gland: 14 nTPM
basal ganglia: 11 nTPM
hypothalamus: 11 nTPM
cerebral cortex: 10 nTPM

Single-cell type

somatotrophs: 137 nCPM
lactotrophs: 133 nCPM
rod photoreceptor cells: 114 nCPM
thyrotrophs: 95 nCPM
retinal horizontal cells: 84 nCPM
cone photoreceptor cells: 83 nCPM

Immune cell

naive CD8 T-cell: 4.9 nTPM
naive CD4 T-cell: 4.4 nTPM
T-reg: 3.1 nTPM
memory CD8 T-cell: 3 nTPM
gdT-cell: 2.7 nTPM
memory CD4 T-cell: 2.7 nTPM

Brain region

cerebellum: 25 nTPM
hypothalamus: 22 nTPM
cerebral cortex: 19 nTPM
basal ganglia: 17 nTPM
hippocampal formation: 14 nTPM
white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0.39
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF540 as an antibody target. Whether an autoantibody or antibody against ZNF540 could matter depends on whether native ZNF540 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF540 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF540 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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