Seroatlas · Human Serome Atlas

ZNF521

Zinc finger protein 521

Also known as: EHZF, Evi3, ZN521_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96K83
Gene: ZNF521
Ensembl: ENSG00000198795
Chromosome: 18
Canonical length: 1311 aa
Protein class: Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables protein domain specific binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neuron fate commitment. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1311 residues, UniProt reviewed canonical sequence.

>Q96K83|ZNF521
     1  MSRRKQAKPR SLKDPNCKLE DKTEDGEALD CKKRPEDGEE LEDEAVHSCD SCLQVFESLS
    61  DITEHKINQC QLTDGVDVED DPTCSWPASS PSSKDQTSPS HGEGCDFGEE EGGPGLPYPC
   121  QFCDKSFSRL SYLKHHEQSH SDKLPFKCTY CSRLFKHKRS RDRHIKLHTG DKKYHCSECD
   181  AAFSRSDHLK IHLKTHTSNK PYKCAICRRG FLSSSSLHGH MQVHERNKDG SQSGSRMEDW
   241  KMKDTQKCSQ CEEGFDFPED LQKHIAECHP ECSPNEDRAA LQCVYCHELF VEETSLMNHM
   301  EQVHSGEKKN SCSICSESFH TVEELYSHMD SHQQPESCNH SNSPSLVTVG YTSVSSTTPD
   361  SNLSVDSSTM VEAAPPIPKS RGRKRAAQQT PDMTGPSSKQ AKVTYSCIYC NKQLFSSLAV
   421  LQIHLKTMHL DKPEQAHICQ YCLEVLPSLY NLNEHLKQVH EAQDPGLIVS AMPAIVYQCN
   481  FCSEVVNDLN TLQEHIRCSH GFANPAAKDS NAFFCPHCYM GFLTDSSLEE HIRQVHCDLS
   541  GSRFGSPVLG TPKEPVVEVY SCSYCTNSPI FNSVLKLNKH IKENHKNIPL ALNYIHNGKK
   601  SRALSPLSPV AIEQTSLKMM QAVGGAPARP TGEYICNQCG AKYTSLDSFQ THLKTHLDTV
   661  LPKLTCPQCN KEFPNQESLL KHVTIHFMIT STYYICESCD KQFTSVDDLQ KHLLDMHTFV
   721  FFRCTLCQEV FDSKVSIQLH LAVKHSNEKK VYRCTSCNWD FRNETDLQLH VKHNHLENQG
   781  KVHKCIFCGE SFGTEVELQC HITTHSKKYN CKFCSKAFHA IILLEKHLRE KHCVFETKTP
   841  NCGTNGASEQ VQKEEVELQT LLTNSQESHN SHDGSEEDVD TSEPMYGCDI CGAAYTMETL
   901  LQNHQLRDHN IRPGESAIVK KKAELIKGNY KCNVCSRTFF SENGLREHMQ THLGPVKHYM
   961  CPICGERFPS LLTLTEHKVT HSKSLDTGNC RICKMPLQSE EEFLEHCQMH PDLRNSLTGF
  1021  RCVVCMQTVT STLELKIHGT FHMQKTGNGS AVQTTGRGQH VQKLYKCASC LKEFRSKQDL
  1081  VKLDINGLPY GLCAGCVNLS KSASPGINVP PGTNRPGLGQ NENLSAIEGK GKVGGLKTRC
  1141  SSCNVKFESE SELQNHIQTI HRELVPDSNS TQLKTPQVSP MPRISPSQSD EKKTYQCIKC
  1201  QMVFYNEWDI QVHVANHMID EGLNHECKLC SQTFDSPAKL QCHLIEHSFE GMGGTFKCPV
  1261  CFTVFVQANK LQQHIFSAHG QEDKIYDCTQ CPQKFFFQTE LQNHTMTQHS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF521 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 59 nTPM
ovary: 22 nTPM
spleen: 20 nTPM
endometrium: 14 nTPM
adipose tissue: 13 nTPM
smooth muscle: 13 nTPM

Single-cell type

pituitary stem cells: 1,120 nCPM
choroid plexus epithelial cells: 1,005 nCPM
lymphatic endothelial cells: 563 nCPM
pituicytes/fscs: 518 nCPM
fibro-adipogenic progenitors: 400 nCPM
astrocytes: 315 nCPM

Immune cell

basophil: 11 nTPM
plasmacytoid DC: 8.8 nTPM
NK-cell: 1.6 nTPM
total PBMC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 204 nTPM
choroid plexus: 66 nTPM
pons: 47 nTPM
medulla oblongata: 35 nTPM
hypothalamus: 33 nTPM
midbrain: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 2.45
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF521 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF521 as an antibody target. Whether an autoantibody or antibody against ZNF521 could matter depends on whether native ZNF521 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF521 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF521 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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