Seroatlas · Human Serome Atlas

ZNF517

Zinc finger protein 517

Also known as: ZN517_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMY9
Gene: ZNF517
Ensembl: ENSG00000197363
Chromosome: 8
Canonical length: 492 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q6ZMY9|ZNF517
     1  MAMALPMPGP QEAVVFEDVA VYFTRIEWSC LAPDQQALYR DVMLENYGNL ASLGFLVAKP
    61  ALISLLEQGE EPGALILQVA EQSVAKASLC TDSRMEAGIM ESPLQRKLSR QAGLPGTVWG
   121  CLPWGHPVGG HPAPPHPHGG PEDGSDKPTH PRAREHSASP RVLQEDLGRP VGSSAPRYRC
   181  VCGKAFRYNS LLLRHQIIHT GAKPFQCTEC GKAFKQSSIL LRHQLIHTEE KPFQCGECGK
   241  AFRQSTQLAA HHRVHTRERP YACGECGKAF SRSSRLLQHQ KFHTGEKPFA CTECGKAFCR
   301  RFTLNEHGRI HSGERPYRCL RCGQRFIRGS SLLKHHRLHA QEGAQDGGVG QGALLGAAQR
   361  PQAGDPPHEC PVCGRPFRHN SLLLLHLRLH TGEKPFECAE CGKAFGRKSN LTLHQKIHTK
   421  EKPFACTECG KAFRRSYTLN EHYRLHSGER PYRCRACGRA CSRLSTLIQH QKVHGREPGE
   481  DTEGRRAPCW AS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF517 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 12 nTPM
ovary: 9.9 nTPM
cerebral cortex: 9.7 nTPM
hippocampal formation: 9 nTPM
endometrium: 8.9 nTPM
cervix: 8.7 nTPM

Single-cell type

hepatic stellate cells: 13 nCPM
megakaryocytes: 12 nCPM
epididymal clear cells: 8.2 nCPM
corticotrophs: 7.4 nCPM
myonuclei: 7.1 nCPM
parietal cells: 7.1 nCPM

Immune cell

memory B-cell: 1.5 nTPM
intermediate monocyte: 0.7 nTPM
MAIT T-cell: 0.6 nTPM
T-reg: 0.6 nTPM
gdT-cell: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM

Brain region

hippocampal formation: 19 nTPM
cerebral cortex: 19 nTPM
amygdala: 18 nTPM
pons: 17 nTPM
thalamus: 17 nTPM
cerebellum: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF517 as an antibody target. Whether an autoantibody or antibody against ZNF517 could matter depends on whether native ZNF517 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF517 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF517 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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