Seroatlas · Human Serome Atlas

ZNF511

Zinc finger protein 511

Also known as: MGC30006, Zfp511, ZN511_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NB15
Gene: ZNF511
Ensembl: ENSG00000198546
Chromosome: 10
Canonical length: 252 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>Q8NB15|ZNF511
     1  MQLPPALCAR LAAGPGAAEP LPVERDPAAG AAPFRFVARP VRFPREHQFF EDGDVQRHLY
    61  LQDVIMQVAD VPEKPRVPAF ACQVAGCCQV FDALDDYEHH YHTLHGNVCS FCKRAFPSGH
   121  LLDAHILEWH DSLFQILSER QDMYQCLVEG CTEKFKTSRD RKDHMVRMHL YPADFRFDKP
   181  KKSRSPASAE APGDSGERSE GEAMEICSEP VAASPAPAGE RRIYRHRIPS TICFGQGAAR
   241  GFKSNKKKTK QC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF511 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 46 nTPM
liver: 41 nTPM
colon: 31 nTPM
heart muscle: 30 nTPM
tongue: 30 nTPM
ovary: 30 nTPM

Single-cell type

epicardial cells: 32 nCPM
late primary spermatocytes: 27 nCPM
paneth cells: 23 nCPM
oocytes: 23 nCPM
gastric chief cells: 21 nCPM
parietal cells: 18 nCPM

Immune cell

eosinophil: 70 nTPM
memory B-cell: 68 nTPM
plasmacytoid DC: 67 nTPM
classical monocyte: 62 nTPM
myeloid DC: 62 nTPM
intermediate monocyte: 54 nTPM

Brain region

choroid plexus: 16 nTPM
thalamus: 15 nTPM
medulla oblongata: 15 nTPM
spinal cord: 14 nTPM
white matter: 14 nTPM
cerebral cortex: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF511 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMCO6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF511 as an antibody target. Whether an autoantibody or antibody against ZNF511 could matter depends on whether native ZNF511 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF511 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF511 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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