Seroatlas · Human Serome Atlas

TMCO6

Transmembrane and coiled-coil domain-containing protein 6

Also known as: FLJ39769, PRO1580, TMCO6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DC7
Gene: TMCO6
Ensembl: ENSG00000113119
Chromosome: 5
Canonical length: 493 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q96DC7|TMCO6
     1  MWSRRQGRLR PTVCGVEELR RRRREREAAL RKARREQQLV SKRLLRNDAP EEAGEGCVAA
    61  ILGETEVQQF LRQAQRGTEE KEREGALVSL RRGLQHPETQ QTFIRLEGSM RTLVGLLTSN
   121  QALLQLEAAR CLHELSHSEQ STVAEACLPA TSYLLTYLSS HSSDFIELCL YTLGNLIVES
   181  EAVRRQLLPQ GIVPALAACI QSPHVAVLEA LGYALSQLLQ AEEAPEKIIP SILASTLPQH
   241  MLQMLQPGPK LNPGVAVEFA WCLHYIICSQ VSNPLLIGHG ALSTLGLLLL DLAGAVQKTE
   301  DAGLELLACP VLRCLSNLLT EAAVETVGGQ MQLRDERVVA ALFILLQFFF QKQPSLLPEG
   361  LWLLNNLTAN SPSFCTSLLS LDLIEPLLQL LPVSNVVSVM VLTVLCNVAE KGPAYCQRLW
   421  PGPLLPALLH TLAFSDTEVV GQSLELLHLL FLYQPEAVQV FLQQSGLQAL ERHQEEAQLQ
   481  DRVYALQQTA LQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMCO6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

liver: 13 nTPM
adrenal gland: 11 nTPM
testis: 10 nTPM
salivary gland: 9.3 nTPM
spleen: 7.4 nTPM
esophagus: 7.2 nTPM

Single-cell type

adrenal cortex cells: 27 nCPM
early primary spermatocytes: 22 nCPM
differentiating spermatogonia: 21 nCPM
paneth cells: 16 nCPM
late primary spermatocytes: 15 nCPM
migrating cytotrophoblasts: 14 nCPM

Immune cell

neutrophil: 13 nTPM
basophil: 12 nTPM
non-classical monocyte: 10 nTPM
naive CD4 T-cell: 9.5 nTPM
intermediate monocyte: 9.1 nTPM
T-reg: 8.2 nTPM

Brain region

white matter: 6.1 nTPM
spinal cord: 4.4 nTPM
medulla oblongata: 3.9 nTPM
pons: 3.8 nTPM
hypothalamus: 3.5 nTPM
thalamus: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMCO6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZNF511

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMCO6 as an antibody target. Whether an autoantibody or antibody against TMCO6 could matter depends on whether native TMCO6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMCO6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMCO6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...