Seroatlas · Human Serome Atlas

ZNF503

Zinc finger protein 503

Also known as: FLJ45745, MGC2555, Nlz2, ZN503_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96F45
Gene: ZNF503
Ensembl: ENSG00000165655
Chromosome: 10
Canonical length: 646 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in G1 to G0 transition involved in cell differentiation; negative regulation of cell population proliferation; and negative regulation of gene expression. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

646 residues, UniProt reviewed canonical sequence.

>Q96F45|ZNF503
     1  MSTAPSLSAL RSSKHSGGGG GGGGGGGADP AWTSALSGNS SGPGPGSSPA GSTKPFVHAV
    61  PPSDPLRQAN RLPIKVLKML TARTGHILHP EYLQPLPSTP VSPIELDAKK SPLALLAQTC
   121  SQIGKPDPSP SSKLSSVASN GGGAGGAGGG AAGDKDTKSG PLKLSDIGVE DKSSFKPYSK
   181  PGSDKKEPGG GGGGGGGGGG GGGGVSSEKS GFRVPSATCQ PFTPRTGSPS SSASACSPGG
   241  MLSSAGGAPE GKDDKKDTDV GGGGKGTGGA SAEGGPTGLA HGRISCGGGI NVDVNQHPDG
   301  GPGGKALGSD CGGSSGSSSG SGPSAPTSSS VLGSGLVAPV SPYKPGQTVF PLPPAGMTYP
   361  GSLAGAYAGY PPQFLPHGVA LDPTKPGSLV GAQLAAAAAG SLGCSKPAGS SPLAGASPPS
   421  VMTASLCRDP YCLSYHCASH LAGAAAASAS CAHDPAAAAA ALKSGYPLVY PTHPLHGVHS
   481  SLTAAAAAGA TPPSLAGHPL YPYGFMLPND PLPHICNWVS ANGPCDKRFA TSEELLSHLR
   541  THTAFPGTDK LLSGYPSSSS LASAAAAAMA CHMHIPTSGA PGSPGTLALR SPHHALGLSS
   601  RYHPYSKSPL PTPGAPVPVP AATGPYYSPY ALYGQRLTTA SALGYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF503 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

ovary: 46 nTPM
endometrium: 42 nTPM
adrenal gland: 40 nTPM
cervix: 35 nTPM
pancreas: 25 nTPM
kidney: 25 nTPM

Single-cell type

gastric chief cells: 2.2 nCPM
fallopian tube ciliated cells: 1.7 nCPM
endometrial secretory cells: 1.6 nCPM
schwann cells: 1.5 nCPM
vascular smooth muscle cells: 1.5 nCPM
cardiomyocytes: 1.3 nCPM

Immune cell

classical monocyte: 0.2 nTPM
myeloid DC: 0.2 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 28 nTPM
spinal cord: 24 nTPM
basal ganglia: 23 nTPM
midbrain: 22 nTPM
thalamus: 19 nTPM
pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.95
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF503 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DCAF7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF503 as an antibody target. Whether an autoantibody or antibody against ZNF503 could matter depends on whether native ZNF503 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF503 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF503 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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