ZNF490

Protein identityUniProt · HPA

UniProt accession

Q9ULM2

Gene

ZNF490

Ensembl

ENSG00000188033

Chromosome

19

Canonical length

529 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q9ULM2|ZNF490
     1  MRRNSSLSFQ MERPLEEQVQ SKWSSSQGRT GTGGSDVLQM QNSEHHGQSI KTQTDSISLE
    61  DVAVNFTLEE WALLDPGQRN IYRDVMRATF KNLACIGEKW KDQDIEDEHK NQGRNLRSPM
   121  VEALCENKED CPCGKSTSQI PDLNTNLETP TGLKPCDCSV CGEVFMHQVS LNRHMRSHTE
   181  QKPNECHEYG EKPHKCKECG KTFTRSSSIR THERIHTGEK PYECKECGKA FAFLFSFRNH
   241  IRIHTGETPY ECKECGKAFR YLTALRRHEK NHTGEKPYKC KQCGKAFIYY QPFLTHERTH
   301  TGEKPYECKQ CGKAFSCPTY LRSHEKTHTG EKPFVCRECG RAFFSHSSLR KHVKTHTGVQ
   361  PYTCKKCGEA FKSSSSCEVH ERTHFGEKPY ECKQCGKAFN SSSYLQLHER VHTGEKTYEC
   421  KECGKAFLYS THFRIHERTH TREKPYECKQ CGRVFIYFSH LRRHERSHTG VKPCECKQCG
   481  KAFTCLNSLK VHKRIHTGER PFQCRQCGKA FSYSKSLHVH ERTHSRQKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF490 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

2.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.49

gnomAD pLI

0

gnomAD missense Z

1.25

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• C2H2-type zinc-finger domain-containing protein
• Zinc finger, C2H2 type
• KRAB box
• Zinc-finger double domain

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF490 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRIM28