Seroatlas · Human Serome Atlas

ZNF461

Zinc finger protein 461

Also known as: GIOT-1, MGC33911, ZN461_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAF7
Gene
ZNF461
Ensembl
ENSG00000197808
Chromosome
19
Canonical length
563 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli,Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>Q8TAF7|ZNF461
     1  MAHELVMFRD VAIDVSQEEW ECLNPAQRNL YKEVMLENYS NLVSLGLSVS KPAVISSLEQ
    61  GKEPWMVVRE ETGRWCPGTW KTWGFHNNFL DNNEATDINA DLASRDEPQK LSPKRDIYET
   121  ELSQWVNMEE FKSHSPERSI FSAIWEGNCH FEQHQGQEEG YFRQLMINHE NMPIFSQHTL
   181  LTQEFYDREK ISECKKCRKI FSYHLFFSHH KRTHSKELSE CKECTEIVNT PCLFKQQTIQ
   241  NGDKCNECKE CWKAFVHCSQ LKHLRIHNGE KRYECNECGK AFNYGSELTL HQRIHTGEKP
   301  YECKECGKAF RQRSQLTQHQ RLHTGEKPYE CKQCGKAFIR GFQLTEHLRL HTGEKPYECK
   361  ECGKTFRHRS HLTIHQRIHT GEKPYECREC GKAFSYHSSF SHHQKIHSGK KPYECHECGK
   421  AFCDGLQLTL HQRIHTGEKP YECKECGKTF RQCSHLKRHQ RIHTGEKPHE CMICGKAFRL
   481  HSHLIQHQRI HTGEKPYECK ECGKAFSYHS SFSHHQRIHS GKKPYQCGKA FNHRLQLNLH
   541  QTLHTGEKPV RFPLLPPHPS LAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF461 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
7.5 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 7.5 nTPM
  • retina: 5.5 nTPM
  • ovary: 4 nTPM
  • thyroid gland: 3.7 nTPM
  • basal ganglia: 3.6 nTPM
  • pituitary gland: 3.5 nTPM

Single-cell type

  • late primary spermatocytes: 49 nCPM
  • syncytiotrophoblasts: 28 nCPM
  • brain excitatory neurons: 26 nCPM
  • other brain neurons: 26 nCPM
  • brain inhibitory neurons: 26 nCPM
  • early spermatids: 25 nCPM

Immune cell

  • memory CD8 T-cell: 2.5 nTPM
  • memory CD4 T-cell: 1.9 nTPM
  • T-reg: 1.7 nTPM
  • naive CD4 T-cell: 1.5 nTPM
  • MAIT T-cell: 1.4 nTPM
  • naive B-cell: 1.4 nTPM

Brain region

  • cerebellum: 16 nTPM
  • cerebral cortex: 11 nTPM
  • white matter: 11 nTPM
  • hypothalamus: 10 nTPM
  • basal ganglia: 10 nTPM
  • hippocampal formation: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
0.57
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF461 as an antibody target. Whether an autoantibody or antibody against ZNF461 could matter depends on whether native ZNF461 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF461 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF461 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF461. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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