ZNF436
Zinc finger protein 436
Also known as: KIAA1710, Zfp46, ZN436_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9C0F3
- Gene
- ZNF436
- Ensembl
- ENSG00000125945
- Chromosome
- 1
- Canonical length
- 470 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
470 residues, UniProt reviewed canonical sequence.
>Q9C0F3|ZNF436
1 MAATLLMAGS QAPVTFEDMA MYLTREEWRP LDAAQRDLYR DVMQENYGNV VSLDFEIRSE
61 NEVNPKQEIS EDVQFGTTSE RPAENAEENP ESEEGFESGD RSERQWGDLT AEEWVSYPLQ
121 PVTDLLVHKE VHTGIRYHIC SHCGKAFSQI SDLNRHQKTH TGDRPYKCYE CGKGFSRSSH
181 LIQHQRTHTG ERPYDCNECG KSFGRSSHLI QHQTIHTGEK PHKCNECGKS FCRLSHLIQH
241 QRTHSGEKPY ECEECGKSFS RSSHLAQHQR THTGEKPYEC NECGRGFSER SDLIKHYRVH
301 TGERPYKCDE CGKNFSQNSD LVRHRRAHTG EKPYHCNECG ENFSRISHLV QHQRTHTGEK
361 PYECNACGKS FSRSSHLITH QKIHTGEKPY ECNECWRSFG ERSDLIKHQR THTGEKPYEC
421 VQCGKGFTQS SNLITHQRVH TGEKPYECTE CEKSFSRSSA LIKHKRVHTDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF436 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 15 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 15 nTPM
- ovary: 14 nTPM
- adrenal gland: 14 nTPM
- salivary gland: 13 nTPM
- skin: 11 nTPM
- vagina: 9.3 nTPM
Single-cell type
- bergmann glia: 8.8 nCPM
- choroid plexus epithelial cells: 7 nCPM
- brain excitatory neurons: 5.5 nCPM
- astrocytes: 5.3 nCPM
- papillary tip epithelial cells: 5.3 nCPM
- brain inhibitory neurons: 5.2 nCPM
Immune cell
- NK-cell: 2.6 nTPM
- myeloid DC: 1.1 nTPM
- T-reg: 0.9 nTPM
- intermediate monocyte: 0.8 nTPM
- memory CD8 T-cell: 0.8 nTPM
- naive CD4 T-cell: 0.8 nTPM
Brain region
- medulla oblongata: 9.9 nTPM
- white matter: 8.8 nTPM
- spinal cord: 8.4 nTPM
- hippocampal formation: 8.1 nTPM
- thalamus: 8.1 nTPM
- cerebellum: 7.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.88
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.97
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF436 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF436 as an antibody target. Whether an autoantibody or antibody against ZNF436 could matter depends on whether native ZNF436 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF436 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF436 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...