Seroatlas · Human Serome Atlas

ZNF432

Zinc finger protein 432

Also known as: KIAA0798, ZN432_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94892
Gene
ZNF432
Ensembl
ENSG00000256087
Chromosome
19
Canonical length
652 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables damaged DNA binding activity and protein-macromolecule adaptor activity. Involved in DNA damage response. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>O94892|ZNF432
     1  MINAQELLTL EDVTVEFTWE EWQLLGPFQK DLYRDVMLEI YSNLLSMGYQ VSKPDALSKL
    61  ERGEEPWTME DERHSRICPE NNEVDDHLQD HLENQRMLKS VEQYHEHNAF GNTASQTKSL
   121  CLFRENHDTF ELYIKTLKSN LSLVNQNKSC EINNSTKFSG DGKSFLHGNY EELYSAAKFS
   181  VSTKANSTKS QVSKHQRTHE IEKNHVCSEC GKAFVKKSQL TDHERVHTGE KPYGCTLCAK
   241  VFSRKSRLNE HQRIHKREKS FICSECGKVF TMKSRLIEHQ RTHTGEKPYI CNECGKGFPG
   301  KRNLIVHQRN HTGEKSYICS ECGKGFTGKS MLIIHQRTHT GEKPYICSEC GKGFTTKHYV
   361  IIHQRNHTGE KPYICNECGK GFTMKSRMIE HQRTHTGEKP YICSECGKGF PRKSNLIVHQ
   421  RNHTVEKSYL CSECGKGFTV KSMLIIHQRT HTGEKPYTCS ECGKGFPLKS RLIVHQRTHT
   481  GEKPYRCSEC GKGFIVNSGL MLHQRTHTGE KPYICNECGK GFAFKSNLVV HQRTHTGEKP
   541  FMCSECGKGF TMKRYLIVHQ QIHTEEKSCI CSECGRGFAK ETELALHKQV HTGEKPYGCN
   601  ECGKGFTMKS RLIVHQRTHT GEKPFVCSEC RKAFSSKRNL IVHQRTHNGN KP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF432 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • retina: 23 nTPM
  • pancreas: 17 nTPM
  • adrenal gland: 12 nTPM
  • pituitary gland: 11 nTPM
  • prostate: 11 nTPM
  • epididymis: 8.2 nTPM

Single-cell type

  • rod photoreceptor cells: 57 nCPM
  • cardiomyocytes: 54 nCPM
  • somatotrophs: 43 nCPM
  • podocytes: 41 nCPM
  • lactotrophs: 40 nCPM
  • gonadotrophs: 34 nCPM

Immune cell

  • memory B-cell: 1.9 nTPM
  • naive CD4 T-cell: 1.5 nTPM
  • gdT-cell: 1.4 nTPM
  • eosinophil: 1.3 nTPM
  • intermediate monocyte: 1.3 nTPM
  • naive B-cell: 1.2 nTPM

Brain region

  • choroid plexus: 24 nTPM
  • cerebellum: 17 nTPM
  • hypothalamus: 17 nTPM
  • white matter: 15 nTPM
  • medulla oblongata: 14 nTPM
  • pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
-0.34
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF432 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF432 as an antibody target. Whether an autoantibody or antibody against ZNF432 could matter depends on whether native ZNF432 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF432 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF432 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF432. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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