Seroatlas · Human Serome Atlas

ZNF43

Zinc finger protein 43

Also known as: HTF6, KOX27, ZNF39L1, ZNF43_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17038
Gene: ZNF43
Ensembl: ENSG00000198521
Chromosome: 19
Canonical length: 809 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

809 residues, UniProt reviewed canonical sequence.

>P17038|ZNF43
     1  MGPLTFMDVA IEFCLEEWQC LDIAQQNLYR NVMLENYRNL VFLGIAVSKP DLITCLEQEK
    61  EPWEPMRRHE MVAKPPVMCS HFTQDFWPEQ HIKDPFQKAT LRRYKNCEHK NVHLKKDHKS
   121  VDECKVHRGG YNGFNQCLPA TQSKIFLFDK CVKAFHKFSN SNRHKISHTE KKLFKCKECG
   181  KSFCMLPHLA QHKIIHTRVN FCKCEKCGKA FNCPSIITKH KRINTGEKPY TCEECGKVFN
   241  WSSRLTTHKK NYTRYKLYKC EECGKAFNKS SILTTHKIIR TGEKFYKCKE CAKAFNQSSN
   301  LTEHKKIHPG EKPYKCEECG KAFNWPSTLT KHKRIHTGEK PYTCEECGKA FNQFSNLTTH
   361  KRIHTAEKFY KCTECGEAFS RSSNLTKHKK IHTEKKPYKC EECGKAFKWS SKLTEHKLTH
   421  TGEKPYKCEE CGKAFNWPST LTKHNRIHTG EKPYKCEVCG KAFNQFSNLT THKRIHTAEK
   481  PYKCEECGKA FSRSSNLTKH KKIHIEKKPY KCEECGKAFK WSSKLTEHKI THTGEKPYKC
   541  EECGKAFNHF SILTKHKRIH TGEKPYKCEE CGKAFTQSSN LTTHKKIHTG EKFYKCEECG
   601  KAFTQSSNLT THKKIHTGGK PYKCEECGKA FNQFSTLTKH KIIHTEEKPY KCEECGKAFK
   661  WSSTLTKHKI IHTGEKPYKC EECGKAFKLS STLSTHKIIH TGEKPYKCEK CGKAFNRSSN
   721  LIEHKKIHTG EQPYKCEECG KAFNYSSHLN THKRIHTKEQ PYKCKECGKA FNQYSNLTTH
   781  NKIHTGEKLY KPEDVTVILT TPQTFSNIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 10 nTPM
ovary: 9.6 nTPM
thymus: 9.4 nTPM
testis: 8.2 nTPM
thyroid gland: 8.2 nTPM
lymph node: 7.8 nTPM

Single-cell type

renal connecting tubule cells: 99 nCPM
neutrophil progenitors: 71 nCPM
thymocytes: 71 nCPM
hematopoietic stem cells: 70 nCPM
megakaryocyte-erythroid progenitors: 66 nCPM
renal collecting duct principal cells: 63 nCPM

Immune cell

basophil: 31 nTPM
naive B-cell: 19 nTPM
memory B-cell: 19 nTPM
naive CD4 T-cell: 19 nTPM
naive CD8 T-cell: 13 nTPM
memory CD4 T-cell: 12 nTPM

Brain region

cerebellum: 59 nTPM
white matter: 51 nTPM
hypothalamus: 48 nTPM
cerebral cortex: 46 nTPM
pons: 45 nTPM
basal ganglia: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -0.75
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF43 as an antibody target. Whether an autoantibody or antibody against ZNF43 could matter depends on whether native ZNF43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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