Seroatlas · Human Serome Atlas

ZNF420

Zinc finger protein 420

Also known as: FLJ32191, ZN420_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAQ5
Gene
ZNF420
Ensembl
ENSG00000197050
Chromosome
19
Canonical length
688 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

688 residues, UniProt reviewed canonical sequence.

>Q8TAQ5|ZNF420
     1  MARKLVMFRD VAIDFSQEEW ECLDSAQRDL YRDVMLENYS NLVSLDLPSR CASKDLSPEK
    61  NTYETELSQW EMSDRLENCD LEESNSRDYL EAKGKMEKQQ ENQKEYFRQG MIIYDKMSIF
   121  NQHTYLSQHS RCHSTEKPYK CKECGKAFRR ASHLTQHQSI HTGEKPYECK QCGKAFSRDS
   181  QLSLHQRLHT GEKPYACKEC GKAFTQSSQL ILHHRIHTGE KPYKCEECGK AFIRSSQLTR
   241  HQKVHTGEKP YECKECGKAF TQNSQLTLHQ RLHTGEKLYE CKECRKVFTQ LSQLILHKRI
   301  HTGEKPYECK ECGKAFICGS QLSQHQKIHN GEKPYECKEC GRAFIRGSLL MQHQRIHTGE
   361  KPYKCEECGK AFIRGSQLTQ HQRIHTNEKP YECKECGKMF SHGSQLTQHQ RIHTGEKPYQ
   421  CKECGKAFNR GSLLTRHQRI HTGEKPYECK ECGKTFSRGS ELTQHERIHT GEKPYECKEC
   481  GKSFIRGSQL TQHQRIHTGE KPYECKECRM AFTQSSHLSQ HQRLHTGEKP YVCNECGKAF
   541  ARGLLLIQHQ RIHTGEKPYQ CKECGKAFIR GSQLTQHQRI HTGEKPYECK ECGKAFSHGS
   601  QLTLHQRIHT GEKPYECREC RKAFTQSSHL SRHQRIHTGE KPYQCKECGK AFTRGSQLTQ
   661  HQRIHISEKS FEYKECGIDF SHGSQVYM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF420 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
9.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9.2 nTPM
  • ovary: 7.1 nTPM
  • cerebellum: 6.9 nTPM
  • retina: 6.8 nTPM
  • thyroid gland: 6.2 nTPM
  • tongue: 6.1 nTPM

Single-cell type

  • late spermatids: 267 nCPM
  • early spermatids: 225 nCPM
  • late primary spermatocytes: 163 nCPM
  • cardiomyocytes: 152 nCPM
  • thyrotrophs: 90 nCPM
  • retinal horizontal cells: 88 nCPM

Immune cell

  • T-reg: 14 nTPM
  • naive B-cell: 14 nTPM
  • NK-cell: 12 nTPM
  • naive CD8 T-cell: 12 nTPM
  • naive CD4 T-cell: 11 nTPM
  • memory CD4 T-cell: 11 nTPM

Brain region

  • cerebellum: 12 nTPM
  • pons: 9.6 nTPM
  • white matter: 9 nTPM
  • basal ganglia: 8.6 nTPM
  • hypothalamus: 8.5 nTPM
  • choroid plexus: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
1.77
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF420 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF420 as an antibody target. Whether an autoantibody or antibody against ZNF420 could matter depends on whether native ZNF420 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF420 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF420 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF420. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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