ZNF385B
Zinc finger protein 385B
Also known as: FLJ25270, Z385B_HUMAN, ZNF533
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q569K4
- Gene
- ZNF385B
- Ensembl
- ENSG00000144331
- Chromosome
- 2
- Canonical length
- 471 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli fibrillar center
OverviewNCBI Gene
Enables p53 binding activity. Involved in intrinsic apoptotic signaling pathway by p53 class mediator. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
471 residues, UniProt reviewed canonical sequence.
>Q569K4|ZNF385B
1 MNMANFLRGF EEKGIKNDRP EDQLSKEKKK ILFSFCEVCN IQLNSAAQAQ VHSNGKSHRK
61 RVKQLSDGQP PPPAQASPSS NSSTGSTCHT TTLPALVRTP TLMMQPSLDI KPFMSFPVDS
121 SSAVGLFPNF NTMDPVQKAV INHTFGVSIP PKKKQVISCN VCQLRFNSDS QAEAHYKGSK
181 HAKKVKALDA TKNKPKMVPS KDSAKANPSC SITPITGNNS DKSEDKGKLK ASSSSQPSSS
241 ESGSFLLKSG TTPLPPGAAT SPSKSTNGAP GTVVESEEEK AKKLLYCSLC KVAVNSLSQL
301 EAHNTGSKHK TMVEARNGAG PIKSYPRPGS RLKMQNGSKG SGLQNKTFHC EICDVHVNSE
361 IQLKQHISSR RHKDRVAGKP LKPKYSPYNK LQRSPSILAA KLAFQKDMMK PLAPAFLSSP
421 LAAAAAVSSA LSLPPRPSAS LFQAPAIPPA LLRPGHGPIR ATPASILFAP YLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF385B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 82 nTPM
Expression across tissuesHPA
Tissue
- retina: 82 nTPM
- heart muscle: 23 nTPM
- cerebellum: 23 nTPM
- liver: 18 nTPM
- lung: 17 nTPM
- skeletal muscle: 16 nTPM
Single-cell type
- alveolar cells type 2: 2,772 nCPM
- retinal bipolar cells: 2,655 nCPM
- rod photoreceptor cells: 1,661 nCPM
- transitional alveolar cells: 1,161 nCPM
- sertoli cells: 1,127 nCPM
- myonuclei: 872 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 76 nTPM
- basal ganglia: 73 nTPM
- cerebral cortex: 55 nTPM
- pons: 41 nTPM
- white matter: 38 nTPM
- thalamus: 32 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.78
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.72
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF385B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF385B as an antibody target. Whether an autoantibody or antibody against ZNF385B could matter depends on whether native ZNF385B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF385B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF385B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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